Journal of Applied Physiology AJP: Lung Cellular and Molecular Physiology
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J Appl Physiol 59: 1369-1375, 1985;
8750-7587/85 $5.00
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Journal of Applied Physiology, Vol 59, Issue 5 1369-1375, Copyright © 1985 by American Physiological Society

ARTICLES

Effect of 71 ATA He-O2 on organ blood flow in the rat

L. Aanderud, J. Onarheim and I. Tyssebotn

Cardiac output and organ blood flow to major organs were investigated in awake rats at 1 atmosphere absolute (ATA) air and at 71 ATA He-O2. Radioactively labeled microspheres [15 +/- 1 (SD) micron] were injected into the left ventricle during constant-rate arterial blood sampling at 1 ATA air and subsequently at 71 ATA He-O2. Intra-arterial blood pressure was continuously recorded. The partial pressure of O2 was kept between 0.4 and 0.6 ATA. The results indicate that the mean blood pressure, heart rate, cardiac output, and organ blood flow are essentially unaltered in the rat at 71 ATA except for increased blood flow to the liver (122%, P less than 0.05), whereas the blood flow to the adrenals, the diaphragm, and the leg muscle fell (P less than 0.05).




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