Journal of Applied Physiology
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J Appl Physiol 59: 1055-1060, 1985;
8750-7587/85 $5.00
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Journal of Applied Physiology, Vol 59, Issue 4 1055-1060, Copyright © 1985 by American Physiological Society

ARTICLES

Turnover of phospholipids isolated from fractions of lung lavage fluid

A. Baritussio, R. Carraro, L. Bellina, A. Rossi, R. Bruni, A. Pettenazzo and G. Enzi

To clarify the steps following surfactant secretion, we injected adult rabbits with radioactive palmitate, lavaged the airways, removed the cells, separated by ultracentrifugation lavage components into two fractions (B and C), and followed the labeling of phospholipids of these fractions. The results were compatible with the view that total and saturated phosphatidylcholine are transferred from B to C. Furthermore, the fluxes of total and saturated phosphatidylcholine through fraction C (0.45 and 0.30 mumol . h-1 . g lung-1, respectively) were compatible with the actual estimates of surfactant recycling. The labeling of phosphatidylglycerol ruled out a simple precursor-product relationship between B and C but was compatible with a nonideal first-order relationship. The labeling of phosphatidylinositol, cardiolipin, and phosphatidylethanolamine was incompatible with the existence of a direct precursor-product relationship between B and C. The labeling of total and saturated phosphatidylcholine suggests that fraction B may be made by active surfactant, whereas fraction C may contain surfactant modified for reuptake or for reuptake and catabolism.


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