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J Appl Physiol 59: 832-837, 1985;
8750-7587/85 $5.00
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Journal of Applied Physiology, Vol 59, Issue 3 832-837, Copyright © 1985 by American Physiological Society

ARTICLES

Enhanced metabolic response to caffeine in exercise-trained human subjects

J. LeBlanc, M. Jobin, J. Cote, P. Samson and A. Labrie

The effect of caffeine on resting metabolic rate (RMR) was investigated in eight trained and eight nontrained young male subjects. The ingestion of 4 mg/kg caffeine produced a greater increase of RMR in trained subjects. This effect was associated with a greater increase in plasma free fatty acids and a larger fall in respiratory quotient, indicating an enhanced lipid oxidation following caffeine in exercise-trained subjects. An initial fall in plasma glucose was observed but only in trained subjects, and caffeine did not change plasma insulin in either group studied. Caffeine caused a significant fall in plasma norepinephrine and an increase in plasma epinephrine in both groups of subjects, but this action was significantly greater in trained subjects. It is suggested that the greater increase in RMR observed in trained subjects following caffeine ingestion is related to an enhanced lipid mobilization, possibly produced by a greater epinephrine secretion and by subsequent increased lipid oxidation.


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A. Fahlman, W. C. Lin, W. B. Whitman, and S. R. Kayar
Modulation of decompression sickness risk in pigs with caffeine during H2 biochemical decompression
J Appl Physiol, November 1, 2002; 93(5): 1583 - 1589.
[Abstract] [Full Text] [PDF]


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