Journal of Applied Physiology
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J Appl Physiol 59: 47-55, 1985;
8750-7587/85 $5.00
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Journal of Applied Physiology, Vol 59, Issue 1 47-55, Copyright © 1985 by American Physiological Society

ARTICLES

Polymorphonuclear leukocyte: arachidonate edema

D. M. Shasby, S. S. Shasby and M. J. Peach

Polymorphonuclear leukocytes (PMN) are important participants in many models of acute lung edema. Enhanced metabolism of arachidonate is also characteristic of many of these models. We found that PMN and arachidonate, but neither alone, increased alveolar capillary permeability of isolated perfused lungs and increased transfer of albumin across monolayers of endothelial cells cultured on micropore filters. Inhibition of PMN, but not endothelial cyclooxygenase, blunted the edematous process. Neither PMN proteases nor PMN-derived oxidants were involved. The edemagenic activity was not found in supernatants of PMN and arachidonate, and unstable prostaglandins did not alter endothelial albumin transfer. The edemagenic process was not inhibited by blocking leukotriene synthesis, and endothelial albumin transfer was not increased by direct addition of leukotrienes to endothelium. These data demonstrate that PMN and arachidonate can interact to increase endothelial permeability and that PMN cyclooxygenase activity is important for this process. This interaction is of potential significance to the acute inflammatory process in the lung vasculature.


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S. HAMMERSCHMIDT and H. WAHN
Comparable Effects of HOCl and of FMLP-stimulated PMN on the Circulation in an Isolated Lung Model
Am. J. Respir. Crit. Care Med., September 1, 1997; 156(3): 924 - 931.
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