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J Appl Physiol 59: 242-247, 1985;
8750-7587/85 $5.00
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Journal of Applied Physiology, Vol 59, Issue 1 242-247, Copyright © 1985 by American Physiological Society

ARTICLES

Segmental pulmonary vascular resistance in progressive hydrostatic and permeability edema

C. G. Wang, T. S. Hakim, R. P. Michel and H. K. Chang

We used the in situ blood-perfused left lower lobe preparation of the dog to examine the effect of hydrostatic and permeability edema on the slope and intercept of the vascular pressure-flow (P/Q) relationship and on the longitudinal distribution of vascular resistance with the arterial and venous occlusion technique. Hydrostatic edema (HE) was induced by raising the venous pressure, and permeability edema (PE) was induced with alpha-naphthylthiourea. When the hematocrit (Hct) of the perfusate was kept normal (approximately 40%), HE had no significant effect on either the slope or the intercept of the P/Q relationship or on the distribution of vascular resistance. PE caused a small increase in the intercept of the P/Q relationship and a small rise in the resistance of the vessels in the middle segment. In another series of HE experiments in which Hct was allowed to increase during edema formation, there was a marked increase in vascular resistance. We conclude that edema per se does not increase vascular resistance significantly and that the increases in vascular resistance which were observed previously by other investigators in the isolated lungs may be due to increases in blood hematocrit.


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C.-C. Yu and Y.-L. Lai
In vivo pressure-flow curve in unilateral rat lung ischemia-reperfusion injury
J Appl Physiol, May 1, 2001; 90(5): 1865 - 1870.
[Abstract] [Full Text] [PDF]


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