Journal of Applied Physiology AJP: Endocrinology and Metabolism
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 59: 119-126, 1985;
8750-7587/85 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by McCully, K. K.
Right arrow Articles by Faulkner, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by McCully, K. K.
Right arrow Articles by Faulkner, J. A.

Journal of Applied Physiology, Vol 59, Issue 1 119-126, Copyright © 1985 by American Physiological Society

ARTICLES

Injury to skeletal muscle fibers of mice following lengthening contractions

K. K. McCully and J. A. Faulkner

We tested the hypothesis that lengthening contractions result in greater injury to skeletal muscle fibers than isometric or shortening contractions. Mice were anesthetized with pentobarbital sodium and secured to a platform maintained at 37 degrees C. The distal tendon of the extensor digitorum longus muscle was attached to a servomotor. A protocol consisting of isometric, shortening, or lengthening contractions was performed. After the contraction protocol the distal tendon was reattached, incisions were closed, and the mice were allowed to recover. The muscles were removed after 1-30 days, and maximum isometric force (Po) was measured in vitro at 37 degrees C. Three days after isometric and shortening contractions and sham operations, histological appearance was not different from control and Po was 80% of the control value. Three days after lengthening contractions, histological sections showed that 37 +/- 4% of muscle fibers degenerated and Po was 22 +/- 3% of the control value. Muscle regeneration, first seen at 4 days, was nearly complete by 30 days, when Po was 84 +/- 3% of the control value. We conclude that, with the protocol used, lengthening, but not isometric or shortening contractions, caused significant injury to muscle fibers.


This article has been cited by other articles:


Home page
 Biophys. JHome page
A. Panchangam, D. R. Claflin, M. L. Palmer, and J. A. Faulkner
Magnitude of Sarcomere Extension Correlates with Initial Sarcomere Length during Lengthening of Activated Single Fibers from Soleus Muscle of Rats
Biophys. J., August 15, 2008; 95(4): 1890 - 1901.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Sports. Med.Home page
D W Chapman, M J Newton, Z Zainuddin, P Sacco, and K Nosaka
Work and peak torque during eccentric exercise do not predict changes in markers of muscle damage
Br. J. Sports Med., July 1, 2008; 42(7): 585 - 591.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
G. S. Lynch, J. A. Faulkner, and S. V. Brooks
Force deficits and breakage rates after single lengthening contractions of single fast fibers from unconditioned and conditioned muscles of young and old rats
Am J Physiol Cell Physiol, July 1, 2008; 295(1): C249 - C256.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
N. C. Lockhart and S. V. Brooks
Neutrophil accumulation following passive stretches contributes to adaptations that reduce contraction-induced skeletal muscle injury in mice
J Appl Physiol, April 1, 2008; 104(4): 1109 - 1115.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. C. Kayani, G. L. Close, M. J. Jackson, and A. McArdle
Prolonged treadmill training increases HSP70 in skeletal muscle but does not affect age-related functional deficits
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2008; 294(2): R568 - R576.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. Jubeau, A. Sartorio, P. G. Marinone, F. Agosti, J. V. Hoecke, K. Nosaka, and N. A. Maffiuletti
Comparison between voluntary and stimulated contractions of the quadriceps femoris for growth hormone response and muscle damage
J Appl Physiol, January 1, 2008; 104(1): 75 - 81.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
J. S. Chamberlain, J. Metzger, M. Reyes, D. Townsend, and J. A. Faulkner
Dystrophin-deficient mdx mice display a reduced life span and are susceptible to spontaneous rhabdomyosarcoma
FASEB J, July 1, 2007; 21(9): 2195 - 2204.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. Fredsted, H. Gissel, K. Madsen, and T. Clausen
Causes of excitation-induced muscle cell damage in isometric contractions: mechanical stress or calcium overload?
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2007; 292(6): R2249 - R2258.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
E. P. Rader and J. A. Faulkner
Effect of aging on the recovery following contraction-induced injury in muscles of female mice
J Appl Physiol, September 1, 2006; 101(3): 887 - 892.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
E. P. Rader, W. Song, H. Van Remmen, A. Richardson, and J. A. Faulkner
Raising the antioxidant levels within mouse muscle fibres does not affect contraction-induced injury
Exp Physiol, July 1, 2006; 91(4): 781 - 789.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
N. C. Lockhart and S. V. Brooks
Protection from contraction-induced injury provided to skeletal muscles of young and old mice by passive stretch is not due to a decrease in initial mechanical damage.
J. Gerontol. A Biol. Sci. Med. Sci., June 1, 2006; 61(6): 527 - 533.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
M. D. Boppart, D. J. Burkin, and S. J. Kaufman
{alpha}7beta1-Integrin regulates mechanotransduction and prevents skeletal muscle injury
Am J Physiol Cell Physiol, June 1, 2006; 290(6): C1660 - C1665.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. A. Butterfield and W. Herzog
Effect of altering starting length and activation timing of muscle on fiber strain and muscle damage
J Appl Physiol, May 1, 2006; 100(5): 1489 - 1498.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
E. P. Rader and J. A. Faulkner
Recovery from contraction-induced injury is impaired in weight-bearing muscles of old male mice
J Appl Physiol, February 1, 2006; 100(2): 656 - 661.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
E. R. Hentzen, M. Lahey, D. Peters, L. Mathew, I. A. Barash, J. Friden, and R. L. Lieber
Stress-dependent and -independent expression of the myogenic regulatory factors and the MARP genes after eccentric contractions in rats
J. Physiol., January 1, 2006; 570(1): 157 - 167.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
X. Wang, T-X. Jiang, J. D. Road, D. M. Redenbach, and W. D. Reid
Granulocytosis and increased adhesion molecules after resistive loading of the diaphragm
Eur. Respir. J., November 1, 2005; 26(5): 786 - 794.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
T. Taguchi, J. Sato, and K. Mizumura
Augmented Mechanical Response of Muscle Thin-Fiber Sensory Receptors Recorded from Rat Muscle-Nerve Preparations In Vitro After Eccentric Contraction
J Neurophysiol, October 1, 2005; 94(4): 2822 - 2831.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. A. Butterfield and W. Herzog
Quantification of muscle fiber strain during in vivo repetitive stretch-shortening cycles
J Appl Physiol, August 1, 2005; 99(2): 593 - 602.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Sports. Med.Home page
B R Newcomer, B Sirikul, G R Hunter, E Larson-Meyer, and M Bamman
Exercise over-stress and maximal muscle oxidative metabolism: a 31P magnetic resonance spectroscopy case report
Br. J. Sports Med., May 1, 2005; 39(5): 302 - 306.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
T. Taguchi, T. Matsuda, R. Tamura, J. Sato, and K. Mizumura
Muscular mechanical hyperalgesia revealed by behavioural pain test and c-Fos expression in the spinal dorsal horn after eccentric contraction in rats
J. Physiol., April 1, 2005; 564(1): 259 - 268.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
F. X Pizza, J. M Peterson, J. H Baas, and T. J Koh
Neutrophils contribute to muscle injury and impair its resolution after lengthening contractions in mice
J. Physiol., February 1, 2005; 562(3): 899 - 913.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. J. Patel, R. Das, J. Friden, G. J. Lutz, and R. L. Lieber
Sarcomere strain and heterogeneity correlate with injury to frog skeletal muscle fiber bundles
J Appl Physiol, November 1, 2004; 97(5): 1803 - 1813.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. I. Lewis, M. Fournier, X. Da, H. Li, Z. Mosenifar, R. J. McKenna Jr, and A. H. Cohen
Short-term Influences of Lung Volume Reduction Surgery on the Diaphragm in Emphysematous Hamsters
Am. J. Respir. Crit. Care Med., October 1, 2004; 170(7): 753 - 759.
[Abstract] [Full Text] [PDF]

Home page
 Am J Sports MedHome page
H. Song, K. Nakazato, and H. Nakajima
Effect of Increased Excursion of the Ankle on the Severity of Acute Eccentric Contraction-Induced Strain Injury in the Gastrocnemius: An In Vivo Rat Study
Am. J. Sports Med., July 1, 2004; 32(5): 1263 - 1269.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. P. Ingalls, G. L. Warren, J.-Z. Zhang, S. L. Hamilton, and R. B. Armstrong
Dihydropyridine and ryanodine receptor binding after eccentric contractions in mouse skeletal muscle
J Appl Physiol, May 1, 2004; 96(5): 1619 - 1625.
[Abstract] [Full Text] [PDF]

Home page
 Am J Sports MedHome page
A. Tomiya, T. Aizawa, R. Nagatomi, H. Sensui, and S. Kokubun
Myofibers Express IL-6 After Eccentric Exercise
Am. J. Sports Med., March 1, 2004; 32(2): 503 - 508.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
T. J. Koh and J. Escobedo
Cytoskeletal disruption and small heat shock protein translocation immediately after lengthening contractions
Am J Physiol Cell Physiol, March 1, 2004; 286(3): C713 - C722.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. M. Consolino and S. V. Brooks
Susceptibility to sarcomere injury induced by single stretches of maximally activated muscles of mdx mice
J Appl Physiol, February 1, 2004; 96(2): 633 - 638.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. G. Cutlip, K. B. Geronilla, B. A. Baker, M. L. Kashon, G. R. Miller, and A. W. Schopper
Impact of muscle length during stretch-shortening contractions on real-time and temporal muscle performance measures in rats in vivo
J Appl Physiol, February 1, 2004; 96(2): 507 - 516.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
I. A. Barash, L. Mathew, A. F. Ryan, J. Chen, and R. L. Lieber
Rapid muscle-specific gene expression changes after a single bout of eccentric contractions in the mouse
Am J Physiol Cell Physiol, February 1, 2004; 286(2): C355 - C364.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. R. Rathbone, J. C. Wenke, G. L. Warren, and R. B. Armstrong
Importance of satellite cells in the strength recovery after eccentric contraction-induced muscle injury
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2003; 285(6): R1490 - R1495.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
N. P. Whitehead, D. L. Morgan, J. E. Gregory, and U. Proske
Rises in whole muscle passive tension of mammalian muscle after eccentric contractions at different lengths
J Appl Physiol, September 1, 2003; 95(3): 1224 - 1234.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. A. Faulkner
Terminology for contractions of muscles during shortening, while isometric, and during lengthening
J Appl Physiol, August 1, 2003; 95(2): 455 - 459.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
T. J. Koh, J. M. Peterson, F. X. Pizza, and S. V. Brooks
Passive Stretches Protect Skeletal Muscle of Adult and Old Mice From Lengthening Contraction-Induced Injury
J. Gerontol. A Biol. Sci. Med. Sci., July 1, 2003; 58(7): B592 - 597.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. J. McLoughlin, E. Mylona, T. A. Hornberger, K. A. Esser, and F. X. Pizza
Inflammatory cells in rat skeletal muscle are elevated after electrically stimulated contractions
J Appl Physiol, March 1, 2003; 94(3): 876 - 882.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. B. Gillis and A. A. Biewener
Effects of surface grade on proximal hindlimb muscle strain and activation during rat locomotion
J Appl Physiol, November 1, 2002; 93(5): 1731 - 1743.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
I. A. Barash, D. Peters, J. Friden, G. J. Lutz, and R. L. Lieber
Desmin cytoskeletal modifications after a bout of eccentric exercise in the rat
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2002; 283(4): R958 - R963.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
E. W. Yeung, J.-P. Bourreau, D. G. Allen, and H. J. Ballard
Effect of eccentric contraction-induced injury on force and intracellular pH in rat skeletal muscles
J Appl Physiol, January 1, 2002; 92(1): 93 - 99.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. J. Koh and S. V. Brooks
Lengthening contractions are not required to induce protection from contraction-induced muscle injury
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2001; 281(1): R155 - R161.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. Hayot, E. Barreiro, A. Perez, G. Czaika, A. S. Comtois, and A. E. Grassino
Morphological and functional recovery from diaphragm injury: an in vivo rat diaphragm injury model
J Appl Physiol, June 1, 2001; 90(6): 2269 - 2278.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
S. V. Brooks, J. A. Opiteck, and J. A. Faulkner
Conditioning of Skeletal Muscles in Adult and Old Mice for Protection From Contraction-Induced Injury
J. Gerontol. A Biol. Sci. Med. Sci., April 1, 2001; 56(4): 163B - 171.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
W. D. REID and A. N. BELCASTRO
Time Course of Diaphragm Injury and Calpain Activity During Resistive Loading
Am. J. Respir. Crit. Care Med., November 1, 2000; 162(5): 1801 - 1806.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Cell Physiol.Home page
M. Sam, S. Shah, J. Friden, D. J. Milner, Y. Capetanaki, and R. L. Lieber
Desmin knockout muscles generate lower stress and are less vulnerable to injury compared with wild-type muscles
Am J Physiol Cell Physiol, October 1, 2000; 279(4): C1116 - C1122.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. MARCHAND, P. DE LEYN, G. GAYAN-RAMIREZ, F. PALECEK, V. de BOCK, R. DOM, and M. DECRAMER
Lung Volume Reduction Surgery Does Not Improve Diaphragmatic Contractile Properties or Atrophy in Hamsters with Elastase-induced Emphysema
Am. J. Respir. Crit. Care Med., September 1, 2000; 162(3): 1052 - 1057.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
L. E. Gosselin
Attenuation of force deficit after lengthening contractions in soleus muscle from trained rats
J Appl Physiol, April 1, 2000; 88(4): 1254 - 1258.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. A. McBride, B. W. Stockert, F. A. Gorin, and R. C. Carlsen
Stretch-activated ion channels contribute to membrane depolarization after eccentric contractions
J Appl Physiol, January 1, 2000; 88(1): 91 - 101.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. L. Morgan and D. G. Allen
Early events in stretch-induced muscle damage
J Appl Physiol, December 1, 1999; 87(6): 2007 - 2015.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. M. Foley, R. C. Jayaraman, B. M. Prior, J. M. Pivarnik, and R. A. Meyer
MR measurements of muscle damage and adaptation after eccentric exercise
J Appl Physiol, December 1, 1999; 87(6): 2311 - 2318.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. T. Devor and J. A. Faulkner
Regeneration of new fibers in muscles of old rats reduces contraction-induced injury
J Appl Physiol, August 1, 1999; 87(2): 750 - 756.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
G. S. Lynch and J. A. Faulkner
Contraction-induced injury to single muscle fibers: velocity of stretch does not influence the force deficit
Am J Physiol Cell Physiol, December 1, 1998; 275(6): C1548 - C1554.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. P. Ingalls, G. L. Warren, J. H. Williams, C. W. Ward, and R. B. Armstrong
E-C coupling failure in mouse EDL muscle after in vivo eccentric contractions
J Appl Physiol, July 1, 1998; 85(1): 58 - 67.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. Lynn, J. A. Talbot, and D. L. Morgan
Differences in rat skeletal muscles after incline and decline running
J Appl Physiol, July 1, 1998; 85(1): 98 - 104.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. J. Patel, D. Cuizon, O. Mathieu-Costello, J. Friden, and R. L. Lieber
Increased oxidative capacity does not protect skeletal muscle fibers from eccentric contraction-induced injury
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 1998; 274(5): R1300 - R1308.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T.-X. JIANG, W. DARLENE REID, and J. D. ROAD
Delayed Diaphragm Injury and Diaphragm Force Production
Am. J. Respir. Crit. Care Med., March 1, 1998; 157(3): 736 - 742.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. Hortobagyi, J. Houmard, D. Fraser, R. Dudek, J. Lambert, and J. Tracy
Normal forces and myofibrillar disruption after repeated eccentric exercise
J Appl Physiol, February 1, 1998; 84(2): 492 - 498.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. H. Van Der Meulen, A. McArdle, M. J. Jackson, and J. A. Faulkner
Contraction-induced injury to the extensor digitorum longus muscles of rats: the role of vitamin E
J Appl Physiol, September 1, 1997; 83(3): 817 - 823.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. D. Hunter and J. A. Faulkner
Pliometric contraction-induced injury of mouse skeletal muscle: effect of initial length
J Appl Physiol, January 1, 1997; 82(1): 278 - 283.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T.-X. JIANG, W. DARLENE REID, A. BELCASTRO, and J. D. ROAD
Load Dependence of Secondary Diaphragm Inflammation and Injury after Acute Inspiratory Loading
Am. J. Respir. Crit. Care Med., January 1, 1997; 157(1): 230 - 236.
[Abstract] [Full Text]

Home page
 Am J Sports MedHome page
C. T. Hasselman, T. M. Best, A. V. Seaber, and W. E. Garrett JR
A Threshold and Continuum of Injury During Active Stretch of Rabbit Skeletal Muscle
Am. J. Sports Med., January 1, 1995; 23(1): 65 - 73.
[Abstract] [PDF]

Home page
 J Intensive Care MedHome page
M. L. Morganroth and C. M. Grum
Weaning from Mechanical Ventilation
J Intensive Care Med, March 1, 1988; 3(2): 109 - 120.
[Abstract] [PDF]

Home page
 J. Appl. Physiol.Home page
F. X. Pizza, T. J. Koh, S. J. McGregor, and S. V. Brooks
Muscle inflammatory cells after passive stretches, isometric contractions, and lengthening contractions
J Appl Physiol, May 1, 2002; 92(5): 1873 - 1878.
[Abstract] [Full Text] [PDF]