Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 58: 1840-1848, 1985;
8750-7587/85 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bates, J. H.
Right arrow Articles by Milic-Emili, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bates, J. H.
Right arrow Articles by Milic-Emili, J.

Journal of Applied Physiology, Vol 58, Issue 6 1840-1848, Copyright © 1985 by American Physiological Society

ARTICLES

Analysis of the behavior of the respiratory system with constant inspiratory flow

J. H. Bates, A. Rossi and J. Milic-Emili

For a respiratory system with constant compliance and resistance a constant flow can occur during part or all of inspiration in two situations: when the flow is constrained to be constant throughout inspiration, such as is the case with some mechanical ventilators, and when the applied pressure is a ramp (i.e., increasing constantly with time), which may occur during mechanical ventilation and spontaneous breathing. After initial transients in pressure and flow, respectively, have decayed away both situations result in linear volume-time and pressure-time relationships. The slope of the corresponding pressure-volume line then yields an estimate of the total compliance of the respiratory system, and the intercept, divided by the constant flow, provides the total resistance. We have shown theoretically that, for a model composed of two compartments in parallel, the total compliance is the same as the static compliance and equals the sum of the compliances of the two compartments. Furthermore, this compliance is independent of the breathing frequency. However, the total resistance is, in general, a function of both the resistances and the compliances. When the time constants of the two compartments are equal the total resistance assumes its minimum value and becomes independent of the compliances. This minimum value of resistance can be obtained, regardless of the time constants, by dividing the immediate drop in airway opening pressure, obtained after occluding during steady state inspiration, by the inspiratory flow.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
C. Mucignat-Caretta, M. Bondi, A. Rubini, F. Calabrese, and A. Barbato
The olfactory system is affected by steroid aerosol treatment in mice
Am J Physiol Lung Cell Mol Physiol, December 1, 2009; 297(6): L1073 - L1081.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
P. L. Silva, C. S. N. B. Garcia, P. A. Maronas, V. R. Cagido, E. M. Negri, N. R. Damaceno-Rodrigues, G. M. Ventura, P. T. Bozza, W. A. Zin, V. L. Capelozzi, et al.
Early short-term versus prolonged low-dose methylprednisolone therapy in acute lung injury
Eur. Respir. J., March 1, 2009; 33(3): 634 - 645.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
V. Suresh, D. A. Shelley, H.-W. Shin, and S. C. George
Effect of heterogeneous ventilation and nitric oxide production on exhaled nitric oxide profiles
J Appl Physiol, June 1, 2008; 104(6): 1743 - 1752.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
N. Beydon, S. D. Davis, E. Lombardi, J. L. Allen, H. G. M. Arets, P. Aurora, H. Bisgaard, G. M. Davis, F. M. Ducharme, H. Eigen, et al.
An Official American Thoracic Society/European Respiratory Society Statement: Pulmonary Function Testing in Preschool Children
Am. J. Respir. Crit. Care Med., June 15, 2007; 175(12): 1304 - 1345.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. B. Santos, L. K. S. Nagato, N. M. Boechem, E. M. Negri, A. Guimaraes, V. L. Capelozzi, D. S. Faffe, W. A. Zin, and P. R. M. Rocco
Time course of lung parenchyma remodeling in pulmonary and extrapulmonary acute lung injury
J Appl Physiol, January 1, 2006; 100(1): 98 - 106.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. L. S. Menezes, P. T. Bozza, H. C. C. Faria Neto, A. P. Laranjeira, E. M. Negri, V. L. Capelozzi, W. A. Zin, and P. R. M. Rocco
Pulmonary and extrapulmonary acute lung injury: inflammatory and ultrastructural analyses
J Appl Physiol, May 1, 2005; 98(5): 1777 - 1783.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. G. Xisto, L. L. Farias, H. C. Ferreira, M. R. Picanco, D. Amitrano, J. R. Lapa e Silva, E. M. Negri, T. Mauad, D. Carnielli, L. F. F. Silva, et al.
Lung Parenchyma Remodeling in a Murine Model of Chronic Allergic Inflammation
Am. J. Respir. Crit. Care Med., April 15, 2005; 171(8): 829 - 837.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
C. A. Volta, V. Alvisi, S. Petrini, S. Zardi, E. Marangoni, R. Ragazzi, M. Capuzzo, and R. Alvisi
The Effect of Volatile Anesthetics on Respiratory System Resistance in Patients with Chronic Obstructive Pulmonary Disease
Anesth. Analg., February 1, 2005; 100(2): 348 - 353.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. L. Farias, D. S. Faffe, D. G. Xisto, M. C. E. Santana, R. Lassance, L. F. M. Prota, M. B. Amato, M. M. Morales, W. A. Zin, and P. R. M. Rocco
Positive end-expiratory pressure prevents lung mechanical stress caused by recruitment/derecruitment
J Appl Physiol, January 1, 2005; 98(1): 53 - 61.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. M. Dias, C. P. Passaro, V. R. Cagido, M. Einicker-Lamas, J. Lowe, E. M. Negri, V. L. Capelozzi, W. A. Zin, and P. R. M. Rocco
Effects of undernutrition on respiratory mechanics and lung parenchyma remodeling
J Appl Physiol, November 1, 2004; 97(5): 1888 - 1896.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
A. Peratoner, C. S. Nascimento, M. C. E. Santana, R. A. Cadete, E. M. Negri, A. Gullo, P. R. M. Rocco, and W. A. Zin
Effects of propofol on respiratory mechanic and lung histology in normal rats
Br. J. Anaesth., May 1, 2004; 92(5): 737 - 740.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
C. Rylander, M. Hogman, G. Perchiazzi, A. Magnusson, and G. Hedenstierna
Functional Residual Capacity and Respiratory Mechanics as Indicators of Aeration and Collapse in Experimental Lung Injury
Anesth. Analg., March 1, 2004; 98(3): 782 - 789.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
G. Perchiazzi, R. Giuliani, L. Ruggiero, T. Fiore, and G. Hedenstierna
Estimating Respiratory System Compliance During Mechanical Ventilation Using Artificial Neural Networks
Anesth. Analg., October 1, 2003; 97(4): 1143 - 1148.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. R. M. Rocco, A. B. Souza, D. S. Faffe, C. P. Passaro, F. B. Santos, E. M. Negri, J. G. M. Lima, R. S. Contador, V. L. Capelozzi, and W. A. Zin
Effect of Corticosteroid on Lung Parenchyma Remodeling at an Early Phase of Acute Lung Injury
Am. J. Respir. Crit. Care Med., September 15, 2003; 168(6): 677 - 684.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
P.P. Terragni, G.L. Rosboch, A. Lisi, A.G. Viale, and V.M. Ranieri
How respiratory system mechanics may help in minimising ventilator-induced lung injury in ARDS patients
Eur. Respir. J., August 1, 2003; 22(42_suppl): 15s - 21s.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H. Schneider, S. P. Patil, S. Canisius, E. A. Gladmon, A. R. Schwartz, C. P. O'Donnell, P. L. Smith, and C. G. Tankersley
Hypercapnic duty cycle is an intermediate physiological phenotype linked to mouse chromosome 5
J Appl Physiol, July 1, 2003; 95(1): 11 - 19.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
I. de Chazal and R. D. Hubmayr
Novel aspects of pulmonary mechanics in intensive care
Br. J. Anaesth., July 1, 2003; 91(1): 81 - 91.
[Full Text] [PDF]

Home page
 Anesth. Analg.Home page
B. Babik, T. Asztalos, F. Petak, Z. I. Deak, and Z. Hantos
Changes in Respiratory Mechanics During Cardiac Surgery
Anesth. Analg., May 1, 2003; 96(5): 1280 - 1287.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
M. Gama de Abreu, M. Heintz, A. Heller, R. Szechenyi, D. M. Albrecht, and T. Koch
One-Lung Ventilation with High Tidal Volumes and Zero Positive End-Expiratory Pressure Is Injurious in the Isolated Rabbit Lung Model
Anesth. Analg., January 1, 2003; 96(1): 220 - 228.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
B. Babik, F. Petak, T. Asztalos, Z.I. Deak, G. Bogats, and Z. Hantos
Components of respiratory resistance monitored in mechanically ventilated patients
Eur. Respir. J., December 1, 2002; 20(6): 1538 - 1544.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
M. de Perrot, Y. Imai, G. A. Volgyesi, T. K. Waddell, M. Liu, J. B. Mullen, K. McRae, H. Zhang, A. S. Slutsky, V. M. Ranieri, et al.
Effect of ventilator-induced lung injury on the development of reperfusion injury in a rat lung transplant model
J. Thorac. Cardiovasc. Surg., December 1, 2002; 124(6): 1137 - 1144.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. N. Lorenz
A practical guide to evaluating cardiovascular, renal, and pulmonary function in mice
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2002; 282(6): R1565 - R1582.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
E. Kondili, G. Prinianakis, H. Athanasakis, and D. Georgopoulos
Lung emptying in patients with acute respiratory distress syndrome: effects of positive end-expiratory pressure
Eur. Respir. J., May 1, 2002; 19(5): 811 - 819.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
J.-H. Baumert, M. Reyle-Hahn, K. Hecker, R. Tenbrinck, R. Kuhlen, and R. Rossaint
Increased airway resistance during xenon anaesthesia in pigs is attributed to physical properties of the gas
Br. J. Anaesth., April 1, 2002; 88(4): 540 - 545.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
J. O. C. Auler Jr., E. Miyoshi, C. R. Fernandes, F. E. Bensenor, L. Elias, and J. Bonassa
The Effects of Abdominal Opening on Respiratory Mechanics During General Anesthesia in Normal and Morbidly Obese Patients: A Comparative Study
Anesth. Analg., March 1, 2002; 94(3): 741 - 748.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. R. M. ROCCO, E. M. NEGRI, P. M. KURTZ, F. P. VASCONCELLOS, G. H. SILVA, V. L. CAPELOZZI, P. V. ROMERO, and W. A. ZIN
Lung Tissue Mechanics and Extracellular Matrix Remodeling in Acute Lung Injury
Am. J. Respir. Crit. Care Med., September 15, 2001; 164(6): 1067 - 1071.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. C. F. Correa, P. B. Ciminelli, H. Falcao, B. J. C. Alcantara, R. S. Contador, A. S. Medeiros, W. A. Zin, and P. R. M. Rocco
Respiratory mechanics and lung histology in normal rats anesthetized with sevoflurane
J Appl Physiol, August 1, 2001; 91(2): 803 - 810.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
K. Muramatsu, K. Yukitake, M. Nakamura, I. Matsumoto, and Y. Motohiro
Monitoring of nonlinear respiratory elastance using a multiple linear regression analysis
Eur. Respir. J., June 1, 2001; 17(6): 1158 - 1166.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. Perchiazzi, M. Hogman, C. Rylander, R. Giuliani, T. Fiore, and G. Hedenstierna
Assessment of respiratory system mechanics by artificial neural networks: an exploratory study
J Appl Physiol, May 1, 2001; 90(5): 1817 - 1824.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
Q. LU, A. CAPDEROU, P. CLUZEL, E. MOURGEON, L. ABDENNOUR, J.-D. LAW-KOUNE, C. STRAUS, P. GRENIER, M. ZELTER, and J.-J. ROUBY
A Computed Tomographic Scan Assessment of Endotracheal Suctioning-Induced Bronchoconstriction in Ventilated Sheep
Am. J. Respir. Crit. Care Med., November 1, 2000; 162(5): 1898 - 1904.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
G. Nucci, M. Mergoni, C. Bricchi, G. Polese, C. Cobelli, and A. Rossi
On-line monitoring of intrinsic PEEP in ventilator-dependent patients
J Appl Physiol, September 1, 2000; 89(3): 985 - 995.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. A. Volgyesi, L. N. Tremblay, P. Webster, N. Zamel, and A. S. Slutsky
A new ventilator for monitoring lung mechanics in small animals
J Appl Physiol, August 1, 2000; 89(2): 413 - 421.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
S. L.S. Menezes, P. S.C. Chagas, A. V. Macedo-Neto, V. C.T. Santos, P. R.M. Rocco, and W. A. Zin
Suture or Prosthetic Reconstruction of Experimental Diaphragmatic Defects
Chest, May 1, 2000; 117(5): 1443 - 1448.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. KOUTSOUKOU, A. ARMAGANIDIS, C. STAVRAKAKI-KALLERGI, T. VASSILAKOPOULOS, A. LYMBERIS, C. ROUSSOS, and J. MILIC-EMILI
Expiratory Flow Limitation and Intrinsic Positive End-Expiratory Pressure at Zero Positive End-Expiratory Pressure in Patients with Adult Respiratory Distress Syndrome
Am. J. Respir. Crit. Care Med., May 1, 2000; 161(5): 1590 - 1596.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. H. GAVETT, S. L. MADISON, M. A. STEVENS, and D. L. COSTA
Residual Oil Fly Ash Amplifies Allergic Cytokines, Airway Responsiveness, and Inflammation in Mice
Am. J. Respir. Crit. Care Med., December 1, 1999; 160(6): 1897 - 1904.
[Abstract] [Full Text]

Home page
 ChestHome page
A. Jubran
Advances in Respiratory Monitoring During Mechanical Ventilation
Chest, November 1, 1999; 116(5): 1416 - 1425.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
Q. LU, S. R. R. VIEIRA, J. RICHECOEUR, L. PUYBASSET, P. KALFON, P. CORIAT, and J.-J. ROUBY
A Simple Automated Method for Measuring Pressure-Volume Curves during Mechanical Ventilation
Am. J. Respir. Crit. Care Med., January 1, 1999; 159(1): 275 - 282.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. VASSILAKOPOULOS, S. ZAKYNTHINOS, and C. ROUSSOS
The Tension-Time Index and the Frequency/ Tidal Volume Ratio Are the Major Pathophysiologic Determinants of Weaning Failure and Success
Am. J. Respir. Crit. Care Med., August 1, 1998; 158(2): 378 - 385.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. JUBRAN, F. LAGHI, M. MAZUR, S. PARTHASARATHY, E. R. GARRITY Jr., P. J. FAHEY, and M. J. TOBIN
Partitioning of Lung and Chest-wall Mechanics Before and After Lung-volume-reduction Surgery
Am. J. Respir. Crit. Care Med., July 1, 1998; 158(1): 306 - 310.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. DHAND and M. J. TOBIN
Inhaled Bronchodilator Therapy in Mechanically Ventilated Patients
Am. J. Respir. Crit. Care Med., July 1, 1997; 156(1): 3 - 10.
[Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. GEORGOPOULOS, I. MITROUSKA, Z. BSHOUTY, K. WEBSTER, D. PATAKAS, and M. YOUNES
Respiratory Response to CO2 during Pressure-support Ventilation in Conscious Normal Humans
Am. J. Respir. Crit. Care Med., July 1, 1997; 156(1): 146 - 154.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
P. Pelosi, M. Croci, I. Ravagnan, M. Cerisara, P. Vicardi, A. Lissoni, and L. Gattinoni
Respiratory system mechanics in sedated, paralyzed, morbidly obese patients
J Appl Physiol, March 1, 1997; 82(3): 811 - 818.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online