Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 58: 1463-1468, 1985;
8750-7587/85 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hutchison, A. A.
Right arrow Articles by Brigham, K. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hutchison, A. A.
Right arrow Articles by Brigham, K. L.

Journal of Applied Physiology, Vol 58, Issue 5 1463-1468, Copyright © 1985 by American Physiological Society

ARTICLES

Effect of endotoxemia on hypoxic pulmonary vasoconstriction in unanesthetized sheep

A. A. Hutchison, M. L. Ogletree, J. R. Snapper and K. L. Brigham

This study examined the effect of acute endotoxemia on hypoxic pulmonary vasoconstriction (HPV) in awake sheep. Thirteen sheep were chronically instrumented with Silastic catheters in the pulmonary artery, left atrium, jugular vein, and carotid artery; with a Swan-Ganz catheter in the main pulmonary artery; with a chronic lung lymph fistula; and with a tracheostomy. Base-line HPV was determined by measuring the change in pulmonary vascular resistance (PVR) while sheep breathed 12% O2 for 7 min. Concentrations of immunoreactive 6-keto-PGF1 alpha and thromboxane B2 (TXB2) were measured in lung lymph during the hypoxic challenge. Escherichia coli endotoxin (0.2-0.5 micrograms/kg) was infused intravenously. Four hours after endotoxemia, HPV was measured. In five sheep, meclofenamate was infused at 4.5 h after endotoxemia and HPV measured again. During the base-line hypoxic challenge, PVR increased by 36 +/- 9% (mean +/- SE). There was no significant change in lung lymph 6-keto-PGF1 alpha or TXB2 levels with hypoxia. Twelve of the 13 sheep showed a decrease in HPV 4 h after endotoxemia; the mean change in PVR with hypoxia was -8 +/- 5%, which was significantly (P less than 0.05) reduced compared with base-line HPV. The infusion of meclofenamate at 4.5 h after endotoxin did not restore HPV.


This article has been cited by other articles:


Home page
 Innate ImmunityHome page
H. Yamamoto, T. Koizumi, T. Kaneki, K. Fujimoto, K. Kubo, and T. Honda
Direct hemoperfusion with polymyxin B-immobilized fiber improves shock and hypoxemia during endotoxemia in anesthetized sheep
Innate Immunity, December 1, 2002; 8(6): 419 - 426.
[Abstract] [PDF]

Home page
 J. Appl. Physiol.Home page
J. C. Richard, M. Janier, F. Lavenne, V. Berthier, D. Lebars, G. Annat, F. Decailliot, and C. Guerin
Effect of position, nitric oxide, and almitrine on lung perfusion in a porcine model of acute lung injury
J Appl Physiol, December 1, 2002; 93(6): 2181 - 2191.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Z. M. N. Quezado, C. Natanson, W. Karzai, R. L. Danner, C. A. Koev, Y. Fitz, D. P. Dolan, S. Richmond, S. M. Banks, L. Wilson, et al.
Cardiopulmonary effects of inhaled nitric oxide in normal dogs and during E. coli pneumonia and sepsis
J Appl Physiol, January 1, 1998; 84(1): 107 - 115.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. R. FISCHER, D. J. DEYO, H. G. BONE, R. MCGUIRE, L. D. TRABER, and D. L. TRABER
Nitric Oxide Synthase Inhibition Restores Hypoxic Pulmonary Vasoconstriction in Sepsis
Am. J. Respir. Crit. Care Med., September 1, 1997; 156(3): 833 - 839.
[Abstract] [Full Text] [PDF]

Home page
 J Intensive Care MedHome page
M. V. Cutaia and S. Rounds
Analytic Reviews : Hypoxic Pulmonary Vasoconstriction: Physiology and Pathophysiology
J Intensive Care Med, September 1, 1989; 4(5): 186 - 191.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online