Journal of Applied Physiology, Vol 57, Issue 6 1817-1823, Copyright © 1984 by American Physiological Society
Estimation of isogravimetric capillary pressure by a filtration method in skeletal muscle and lung
R. J. Korthuis, M. I. Townsley, B. Rippe and A. E. Taylor
Pre- to postcapillary resistance ratios (Ra/Rv) and isogravimetric
capillary pressures (Pc,i) were estimated using a modified filtration
method and compared with estimates obtained by application of traditional
isogravimetric techniques in isolated rat hindquarters and canine lungs.
Pc,i's and Ra/Rv's were estimated using both methods in rat hindquarters
perfused with whole blood or an artificial plasma and in blood-perfused
canine lung. In each of the three experimental conditions studied, the
modified filtration method yielded the same Pc,i and Ra/Rv as the
isogravimetric technique. Maximal vasodilation of the rat hindquarter with
papaverine reduced Ra/Rv approximately fourfold to a level which was not
different from that obtained in hindquarters perfused with artificial
plasma, although Pc,i was unchanged. These results indicate that the more
easily applied modified filtration method provides an excellent measurement
of Ra/Rv and Pc,i in whole organ studies.
