Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 57: 1754-1759, 1984;
8750-7587/84 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Issekutz, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Issekutz, B., Jr

Journal of Applied Physiology, Vol 57, Issue 6 1754-1759, Copyright © 1984 by American Physiological Society

ARTICLES

Effect of beta-adrenergic blockade on lactate turnover in exercising dogs

B. Issekutz Jr

Dogs with indwelling catheters in the jugular vein and in the carotid artery ran on the treadmill (slope: 15%, speed: 133 m/min). Lactate turnover and glucose turnover were measured using [U-14C]lactate and [3-3H]glucose as tracers, according to the primed constant-rate infusion method. In addition, the participation of plasma glucose in lactate production (Ra-L) was measured with [U-14C]glucose. Propranolol was given either (A) before exercise (250 micrograms/kg, iv) or (B) in form of a primed infusion administered to the dog running at a steady rate. Measurements of plasma propranolol concentration showed that in type A experiments plasma propranolol fell in 45 min below the lower limit of the complete beta-blockade. In the first 15 min of work Ra-L rose rapidly; then it fell below that of the control (exercise) values. During steady exercise, the elevated Ra-L was decreased by propranolol infusion close to resting values. beta-Blockade doubled the response of glucose production, utilization, and metabolic clearance rate to exercise. In exercising dogs approximately 40-50% of Ra-L arises from plasma glucose. This value was increased by the blockade to 85-90%. It is concluded that glycogenolysis in the working muscle has a dual control: 1) an intracellular control operating at the beginning of exercise, and 2) a hormonal control involving epinephrine and the beta-adrenergic receptors.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
T. M. Dean, L. Perreault, R. S. Mazzeo, and T. J. Horton
No effect of menstrual cycle phase on lactate threshold
J Appl Physiol, December 1, 2003; 95(6): 2537 - 2543.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. J. Hamann, K. M. Kelley, and L. B. Gladden
Effect of epinephrine on net lactate uptake by contracting skeletal muscle
J Appl Physiol, December 1, 2001; 91(6): 2635 - 2641.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. J. Chruscinski, D. K. Rohrer, E. Schauble, K. H. Desai, D. Bernstein, and B. K. Kobilka
Targeted Disruption of the beta 2 Adrenergic Receptor Gene
J. Biol. Chem., June 11, 1999; 274(24): 16694 - 16700.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. C. M. Beaufort-Krol, W. G. Zijlstra, J. Takens, M. C. Molenkamp, K. J. Meuzelaar, G. B. Smid, and J. R. G. Kuipers
Lactate kinetics at rest and during exercise in lambs with aortopulmonary shunts
J Appl Physiol, March 1, 1999; 86(3): 832 - 839.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. A. Febbraio, D. L. Lambert, R. L. Starkie, J. Proietto, and M. Hargreaves
Effect of epinephrine on muscle glycogenolysis during exercise in trained men
J Appl Physiol, February 1, 1998; 84(2): 465 - 470.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online