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J Appl Physiol 57: 1409-1411, 1984;
8750-7587/84 $5.00
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Journal of Applied Physiology, Vol 57, Issue 5 1409-1411, Copyright © 1984 by American Physiological Society

ARTICLES

Antagonism by taurine of pressure-induced tremor in the guinea pig

S. C. Gilman, J. M. Hallenbeck, M. J. Ackerman and M. E. Bradley

The tremorogenic effect of high pressure was antagonized in guinea pigs by intravenous treatment with taurine in doses of 250 and 500 mg/kg. Also pretreatment with 250 mg/kg taurine suppressed tremor development as evidenced by increased threshold and decreased amplitude. It is hypothesized that antagonism of pressure-induced tremor by taurine may be related to changes in membrane calcium transport.




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