Journal of Applied Physiology, Vol 57, Issue 4 1195-1201, Copyright © 1984 by American Physiological Society
ECoG and breathing activity in fetal lambs after undercut of cerebral cortex
S. Ioffe, A. H. Jansen and V. Chernick
Reduction of cortical inhibition has been suggested as a possible mechanism
for the transition from episodic fetal to continuous postnatal breathing.
Twelve fetal lambs were chronically decorticated at 112-115 days gestation.
Lateral rectus, neck, and diaphragmatic electromyogram (EMG),
electrocorticogram (ECoG), and tracheal and arterial blood pressure were
monitored after allowing 3 days for recovery. The fetal lambs were studied
for 4-28 days in 2- to 4-h sessions/day. There were no episodes of
low-voltage high-frequency ECoG activity. The mean duration (+/- SD) of
rapid eye movements (REM) measured by lateral rectus EMG [11 +/- 7.9 min
and periods of tonic activity or silence [non-REM (NREM)], 14 +/- 7.4 min]
in decorticated fetuses were not statistically different from REM (12 +/-
5.1 min) and NREM (15 +/- 6.8 min) sleep periods in intact fetuses. After
decortication, the percentage of time (+/- SD) occupied by different states
were phasic diaphragmatic EMG activity 36 +/- 7.8%, tonic diaphragmatic EMG
21 +/- 8.6%, and diaphragmatic silence 43 +/- 14.2%. Phasic diaphragmatic
EMG activity occurred together with REM, the latter being present 45 +/-
3.7% of the time. Despite decortication, between 115 and 125 days gestation
ECoG changed from a trace alternans to a high-voltage low-frequency
pattern. We conclude that the cerebral cortex is not responsible for apnea
during fetal life. In addition, these data suggest that the cerebral cortex
may normally be the source of ECoG synchrony.
