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J Appl Physiol 57: 801-807, 1984;
8750-7587/84 $5.00
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Journal of Applied Physiology, Vol 57, Issue 3 801-807, Copyright © 1984 by American Physiological Society

ARTICLES

Differential inhibitory effect of isoproterenol on contractions of canine airways

J. A. Russell

We examined the inhibitory effect of isoproterenol on contractions of isolated canine airways induced by histamine, 5-hydroxytryptamine (5-HT), and acetylcholine. Airway contractions were matched by using agonist concentrations that produced approximately 60% of the contractile force generated during a previous exposure to 10(-4) M acetylcholine. Concentrations of isoproterenol causing 50% relaxations of histamine-, 5-HT-, and acetylcholine-induced contractions were 9.9 X 10(-9), 3.6 X 10(-8), and 9.0 X 10(-8) M, respectively. Total relaxation of histamine- and 5-HT-induced contractions occurred at 10(-7) and 10(-6) M isoproterenol, respectively, whereas isoproterenol concentrations greater than or equal to 10(-4) M never totally relaxed airways contracted by acetylcholine. We conclude that isoproterenol inhibits airway contractions induced by histamine and 5-HT much more effectively than those induced by acetylcholine.


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