Journal of Applied Physiology Millar Instruments
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J Appl Physiol 57: 731-732, 1984;
8750-7587/84 $5.00
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Journal of Applied Physiology, Vol 57, Issue 3 731-732, Copyright © 1984 by American Physiological Society

ARTICLES

Renal clearance of urea, inulin, and p-aminohippurate in heat-acclimated rats

R. Chayoth, D. Kleinman, J. Kaplanski and U. A. Sod Moriah

Clearance values of urea, inulin, and p-aminohippurate (PAH) were measured in heat-acclimated (HA) rats exposed for 3 wk to 35 degrees C, in control rats (C) exposed to 23 degrees C, and in HA rats deacclimated (DA) for 3 wk. In HA rats, urea clearance was lower by 73%, inulin clearance by 61%, and PAH clearance by 56%, compared with C rats. The clearance values of these substances returned to the control values in DA rats. The data suggest that the low clearance values reflect both reduced renal blood flow and possible changes in the capacity of the glomeruli for filtration and the tubules for either reabsorption or secretion.




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