Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 56: 1507-1511, 1984;
8750-7587/84 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by De Boeck, C.
Right arrow Articles by Chernick, V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by De Boeck, C.
Right arrow Articles by Chernick, V.

Journal of Applied Physiology, Vol 56, Issue 6 1507-1511, Copyright © 1984 by American Physiological Society

ARTICLES

Naloxone reduces decrease in ventilation induced by hypoxia in newborn infants

C. De Boeck, P. Van Reempts, H. Rigatto and V. Chernick

The mechanism responsible for the decrease in ventilation during breathing of low fractional concentration of inspired O2 in the newborn infant is poorly understood. The present study tested the hypothesis that endogenous opiates account for this ventilatory decrease. Eleven healthy newborn infants breathed 15% O2, balance N2 for 5 min following an injection of saline and following an injection of naloxone. Neither injection caused a change in minute ventilation (VE) or ventilatory pattern when the infants were breathing room air. However, the decreased ventilation during hypoxia following naloxone was significantly less than that following saline. VE dropped about 14% following saline but only about 4% following naloxone. However, the adult ventilatory response to hypoxemia, i.e., a relatively sustained increase in VE, was not attained. Naloxone had no influence on the occurrence of periodic breathing during hypoxemia. Thus in the healthy full-term newborn infant, endogenous opiates account only for a part of the decreased ventilation during hypoxemia.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Tabata, H. Kurosawa, Y. Kikuchi, W. Hida, H. Ogawa, S. Okabe, Y. Tun, T. Hattori, and K. Shirato
Role of GABA within the nucleus tractus solitarii in the hypoxic ventilatory decline of awake rats
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2001; 281(5): R1411 - R1419.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online