Journal of Applied Physiology, Vol 56, Issue 4 922-929, Copyright © 1984 by American Physiological Society

ARTICLES

Effects and mechanism of action of terbutaline on diaphragmatic contractility and fatigue

M. Aubier, N. Viires, D. Murciano, G. Medrano, Y. Lecocguic and R. Pariente

We studied the effects of intravenously administered terbutaline on diaphragmatic force and fatigue during electrical stimulation of the diaphragm in 17 anesthetized dogs. The diaphragm was stimulated indirectly through the phrenic nerves with electrodes placed around the fifth roots and directly with electrodes surgically implanted in the abdominal side of each hemidiaphragm. Transdiaphragmatic pressure (Pdi) during direct or indirect supramaximal 2-s stimulation applied over a frequency range of 10-100 Hz was measured with balloon catheters during tracheal occlusion at functional residual capacity. In seven dogs the administration of terbutaline (0.5 mg) had no effect on Pdi at any stimulation frequency applied directly or indirectly. The effect of terbutaline (0.5 mg) on diaphragmatic fatigue was then tested in 10 other dogs. Diaphragmatic fatigue was produced by continuous 20-Hz electrical supramaxial stimulation of the phrenic nerves during 30 min. At the end of the fatigue procedure Pdi decreased by 50 +/- 5 and 30 +/- 8% of control values at 10 and 100 Hz, respectively, for either direct or indirect stimulation. The decrease in Pdi for low frequencies of stimulation (10 and 20 Hz) lasted 100 +/- 18 min, whereas it lasted only 40 +/- 10 min for the high frequencies (50 and 100 Hz). When terbutaline (0.5 mg) was administered after the fatiguing procedure, Pdi increased within 15 min by 20 +/- 4% at 10 Hz and by 12 +/- 3% at 100 Hz for either direct or indirect stimulation.(ABSTRACT TRUNCATED AT 250 WORDS)

This article has been cited by other articles:

				U. R. Mikkelsen, H. Gissel, A. Fredsted, and T. Clausen Excitation-induced cell damage and {beta}2-adrenoceptor agonist stimulated force recovery in rat skeletal muscle Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2006; 290(2): R265 - R272. [Abstract] [Full Text] [PDF]

				W D C Man, N Mustfa, D Nikoletou, S Kaul, N Hart, G F Rafferty, N Donaldson, M I Polkey, and J Moxham Effect of salmeterol on respiratory muscle activity during exercise in poorly reversible COPD Thorax, June 1, 2004; 59(6): 471 - 476. [Abstract] [Full Text] [PDF]

				N. FUJIMURA, S. SUMITA, E. NARIMATSU, Y. NAKAYAMA, Y. SHITINOHE, and A. NAMIKI Effects of Isoproterenol on Diaphragmatic Contractility in Septic Peritonitis Am. J. Respir. Crit. Care Med., February 1, 2000; 161(2): 440 - 446. [Abstract] [Full Text]

				H. F. M. van der Heijden, L. M. A. Heunks, H. Folgering, C. L. A. van Herwaarden, and P. N. R. Dekhuijzen beta 2-Adrenoceptor agonists reduce the decline of rat diaphragm twitch force during severe hypoxia Am J Physiol Lung Cell Mol Physiol, March 1, 1999; 276(3): L474 - L480. [Abstract] [Full Text] [PDF]

				H. F. M. Van Der Heijden, W. Z. Zhan, Y. S. Prakash, P. N. R. Dekhuijzen, and G. C. Sieck Salbutamol enhances isotonic contractile properties of rat diaphragm muscle J Appl Physiol, August 1, 1998; 85(2): 525 - 529. [Abstract] [Full Text] [PDF]

				H. F. M. Van Der Heijden, P. N. R Dekhuijzen, H. Folgering, L. A. Ginsel, and C. L. A. Van Herwaarden Long-term effects of clenbuterol on diaphragm morphology and contractile properties in emphysematous hamsters J Appl Physiol, July 1, 1998; 85(1): 215 - 222. [Abstract] [Full Text] [PDF]

				M. Aubier, D. Murciano, Y. Menu, J. Boczkowski, H. Mal, and R. Pariente Dopamine Effects on Diaphragmatic Strength during Acute Respiratory Failure in Chronic Obstructive Pulmonary Disease Ann Intern Med, January 1, 1989; 110(1): 17 - 23. [Abstract] [PDF]