Journal of Applied Physiology Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 56: 355-363, 1984;
8750-7587/84 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kinasewitz, G. T.
Right arrow Articles by Diana, J. N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kinasewitz, G. T.
Right arrow Articles by Diana, J. N.

Journal of Applied Physiology, Vol 56, Issue 2 355-363, Copyright © 1984 by American Physiological Society

ARTICLES

Role of pulmonary lymphatics and interstitium in visceral pleural fluid exchange

G. T. Kinasewitz, L. J. Groome, R. P. Marshall and J. N. Diana

If the pulmonary lymphatics and/or interstitium of the lung participate in visceral pleural (VP) fluid exchange, then increasing the water content of the interstitial compartment by lymphatic ligation (L) should increase the filtration and/or decrease the absorption of fluid across the VP membrane. To test this hypothesis, the hydraulic conductivity (Lp) and diffusional permeability for protein (Pd) of the visceral pleura were determined in eight spontaneously breathing anesthetized chronic L dogs and seven sham-operated (S) controls. The left lung was enclosed in a water-impermeable membrane, creating a VP space; fluid flux was determined as the filtration or reabsorption of water and protein in the VP space. Intravascular and pleural pressures and the protein concentration of plasma and pleural fluid were monitored during two or more experimental periods in which different mixtures of plasma and saline were introduced in the VP space. At similar pulmonary capillary pressures, the extravascular lung water of the L animals [5.36 (+/- 0.32) g/g dry blood-free lung] was significantly (P less than 0.001) greater than that of the S dogs [3.79 (+/- 0.13)]. The Lp of the L dogs [6.8 (+/- 1.6) X 10(-7) ml X s-1 X cm-2 X Torr-1] was virtually identical (P greater than 0.8) to the 6.7 (+/- 1.4) ml X s-1 X cm-2 X Torr-1 of the S controls. Similarly, Pd in the L group [4.3 (+/- 0.5) X 10(-6) cm/s] was similar (P greater than 0.5) to that of the S animals [5.1 (+/- 1.1) X 10(-6) cm/s]. We conclude that neither the pulmonary lymphatics nor the interstitium of the lung contribute to VP fluid exchange.


This article has been cited by other articles:


Home page
 Physiol. Rev.Home page
S. J. LAI-FOOK
Pleural Mechanics and Fluid Exchange
Physiol Rev, April 1, 2004; 84(2): 385 - 410.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Z. Borok and A. S. Verkman
Lung Edema Clearance: 20 Years of Progress: Invited Review: Role of aquaporin water channels in fluid transport in lung and airways
J Appl Physiol, December 1, 2002; 93(6): 2199 - 2206.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
M. Saarinen, P. Ekman, M. Ikeda, M. Virtala, A. Gronberg, D. T. Y. Yu, H. Arvilommi, and K. Granfors
Invasion of Salmonella into human intestinal epithelial cells is modulated by HLA-B27
Rheumatology, June 1, 2002; 41(6): 651 - 657.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
Y. Song, B. Yang, M. A. Matthay, T. Ma, and A. S. Verkman
Role of aquaporin water channels in pleural fluid dynamics
Am J Physiol Cell Physiol, December 1, 2000; 279(6): C1744 - C1750.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online