Journal of Applied Physiology
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J Appl Physiol 55: 1844-1848, 1983;
8750-7587/83 $5.00
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Journal of Applied Physiology, Vol 55, Issue 6 1844-1848, Copyright © 1983 by American Physiological Society

ARTICLES

Effect of vasoactive intestinal peptide on ion transport across dog tracheal epithelium

I. Nathanson, J. H. Widdicombe and P. J. Barnes

Under short-circuit conditions, vasoactive intestinal peptide (VIP) did not alter net Na+ movement but selectively stimulated net Cl- secretion across dog tracheal epithelium with a high affinity (Km congruent to 10(-8) M). The increase in Cl- secretion was not different from the rise in short-circuit current (Isc). However, stimulation of Cl- secretion was not maximal, because the addition of isoproterenol (10(-6) M) to VIP-treated tissues further increased the Isc by 54%. The effect of exogenous VIP was not blocked by a combination of atropine, phentolamine, propranolol (10(-5) or 10(-6) M), or tetrodotoxin (10(-6) M). Under open-circuit conditions, VIP caused an increase in the net secretion of Cl- and Na+, but the changes did not reach statistical significance. We conclude that VIP acts directly on receptors on the surface of epithelial cells to stimulate active Cl- secretion. The abundance of VIP nerves in the submucosa suggests that VIP may be important in regulation of fluid movement across the epithelium.


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P Heinz-Erian, R. Dey, M Flux, and S. Said
Deficient vasoactive intestinal peptide innervation in the sweat glands of cystic fibrosis patients
Science, September 27, 1985; 229(4720): 1407 - 1408.
[Abstract] [PDF]


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