Journal of Applied Physiology, Vol 55, Issue 6 1660-1664, Copyright © 1983 by American Physiological Society

ARTICLES

Effect of acute exercise and prolonged training on insulin response to intravenous glucose in vivo in rat

D. E. James, K. M. Burleigh, E. W. Kraegen and D. J. Chisholm

Physical training causes hypoinsulinemia and enhanced insulin sensitivity. Insulin sensitivity is also enhanced by a single bout of exercise. However, changes in beta-cell responsiveness with acute exercise are ill defined. To clarify these relationships intravenous glucose tolerance tests were performed in 1) physically trained rats (3 different levels), 48 h after the last bout of exercise; 2) untrained rats, 0.5, 4, and 24 h after a single bout of exercise; or 3) sedentary control rats. The total area under the glucose-stimulated insulin response curve (GSIR) was negatively correlated with total distance run during training (r = -0.45, P less than 0.05), whereas glucose tolerance was improved (P less than 0.005 vs. controls) with intensive training. GSIR was suppressed by 38% (P less than 0.01 vs. controls) 0.5 h after a single bout of exercise. This effect persisted for 4 h but was not present after 24 h. These results indicate that a single bout of exercise induces suppression of GSIR which lasts less than 24 h. In contrast, physical training induces prolonged suppression (for at least 48 h) of GSIR, proportional to the intensity of training, and improved glucose tolerance.

This article has been cited by other articles:

				E. J. Henriksen Exercise Effects of Muscle Insulin Signaling and Action: Invited Review: Effects of acute exercise and exercise training on insulin resistance J Appl Physiol, August 1, 2002; 93(2): 788 - 796. [Abstract] [Full Text] [PDF]

				V. Saengsirisuwan, F. R. Perez, T. R. Kinnick, and E. J. Henriksen Effects of exercise training and antioxidant R-ALA on glucose transport in insulin-sensitive rat skeletal muscle J Appl Physiol, January 1, 2002; 92(1): 50 - 58. [Abstract] [Full Text] [PDF]

				E. B. Arias, L. E. Gosselin, and G. D. Cartee Exercise Training Eliminates Age-Related Differences in Skeletal Muscle Insulin Receptor and IRS-1 Abundance in Rats J. Gerontol. A Biol. Sci. Med. Sci., October 1, 2001; 56(10): B449 - 455. [Abstract] [Full Text] [PDF]

				P. Galassetti, Y. Koyama, R. H. Coker, D. B. Lacy, A. D. Cherrington, and D. H. Wasserman Role of a negative arterial-portal venous glucose gradient in the postexercise state Am J Physiol Endocrinol Metab, December 1, 1999; 277(6): E1038 - E1045. [Abstract] [Full Text] [PDF]

				P. Galassetti, R. H. Coker, D. B. Lacy, A. D. Cherrington, and D. H. Wasserman Prior exercise increases net hepatic glucose uptake during a glucose load Am J Physiol Endocrinol Metab, June 1, 1999; 276(6): E1022 - E1029. [Abstract] [Full Text] [PDF]

				P. Galassetti, K. S. Hamilton, F. K. Gibbons, D. P. Bracy, D. B. Lacy, A. D. Cherrington, and D. H. Wasserman Effect of fast duration on disposition of an intraduodenal glucose load in the conscious dog Am J Physiol Endocrinol Metab, March 1, 1999; 276(3): E543 - E552. [Abstract] [Full Text] [PDF]