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J Appl Physiol 55: 1565-1573, 1983;
8750-7587/83 $5.00
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Journal of Applied Physiology, Vol 55, Issue 5 1565-1573, Copyright © 1983 by American Physiological Society

ARTICLES

Model analysis of respiratory responses to inspiratory resistive loads

W. A. Zin, A. Rossi and J. Milic-Emili

Based on experimental inspiratory driving pressure waveforms and active respiratory impedance data of anesthetized cats, we made model predictions of the factors that determine the immediate (first loaded breath) intrinsic (i.e., nonneural) tidal volume compensation to added inspiratory resistive loads. The time course of driving pressure (P) was given by P = atb, where a is the pressure at 1 s from onset of inspiration and represents the intensity of neuromuscular drive, t is time, and b is a dimensionless index of the shape of the driving pressure wave. For a given value of active respiratory impedance, tidal volume compensation to added resistive loads increases with increasing inspiratory duration and decreasing value of b but is independent of a. Model predictions of load compensation are compared to experimental results.


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 Am. J. Respir. Crit. Care Med.Home page
T. BRACK, A. JUBRAN, and M. J. TOBIN
Effect of Resistive Loading on Variational Activity of Breathing
Am. J. Respir. Crit. Care Med., June 1, 1998; 157(6): 1756 - 1763.
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