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J Appl Physiol 55: 1514-1522, 1983;
8750-7587/83 $5.00
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Journal of Applied Physiology, Vol 55, Issue 5 1514-1522, Copyright © 1983 by American Physiological Society

ARTICLES

Effects of hypoproteinemia and increased vascular pressure on lung fluid balance in sheep

G. C. Kramer, B. A. Harms, B. I. Bodai, E. M. Renkin and R. H. Demling

We compared the effects of a sustained decrease in plasma oncotic pressure on lung fluid balance with those of an increase in vascular pressure in six unanesthetized sheep. Initial plasma protein concentration of 58.0 +/- 2.2 (SE) mg/ml was quickly reduced to 34.0 +/- 1.4 mg/ml via plasmapheresis and held at this value for 24 h. Red cells were returned with lactated Ringer solution infused at a rate adjusted to maintain central venous pressure; cardiac output and pulmonary vascular pressures also remained at base line. Steady-state lymph flows increased from a base-line value of 8.8 +/- 3.2 to 20.1 +/- 5.6 ml/h, while the lymph-to-plasma protein concentration ratio ( [L/P] ) decreased from 0.65 +/- 0.03 to 0.44 +/- 0.04. Decreased lymph protein resulted in reestablishment of base-line plasma-to-lymph oncotic gradient. The increased lymph flow was not the result of increased filtration forces, since all vascular pressures and the oncotic gradient were unchanged; nor was it due entirely to increased surface area since [L/P] was decreased. The decrease in plasma oncotic pressure, delta pi P, was twice as effective at increasing lymph flow (1.66 ml X h-1 X mmHg-1, delta pi P) as an equivalent increase in microvascular pressure, delta PC, at normal plasma protein concentration (0.82 ml X h-1 X mmHg-1, delta PC). Elevation of microvascular pressure during hypoproteinemia had a greater effect on lymph flow (1.44 ml X h-1 X mmHg-1, delta PC) than at normal plasma protein concentration.(ABSTRACT TRUNCATED AT 250 WORDS)


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 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
R. D. Manning Jr.
Chronic lymph flow responses to hyperproteinemia
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 1998; 275(1): R135 - R140.
[Abstract] [Full Text] [PDF]


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