Journal of Applied Physiology, Vol 55, Issue 3 964-968, Copyright © 1983 by American Physiological Society

ARTICLES

Comparison of isogravimetric and venous occlusion capillary pressures in isolated dog lungs

J. C. Parker, P. R. Kvietys, K. P. Ryan and A. E. Taylor

Venous occlusion capillary pressures (Pcv) were simultaneously compared with isogravimetric capillary pressures (PcI) in the same isolated perfused dog lung preparations. For 26 determinations, PcI averaged 1.23 +/- 0.22 (SE) mmHg higher than Pcv. However, the two measurements of capillary pressure were highly correlated (r = 0.99), and the following regression equation was obtained: Pcv = 1.12 PcI - 2.1. Pcv could be easily measured several times in the same preparation, either by total venous occlusion or regional venous occlusion using a Swan-Ganz balloon catheter. In addition, Pcv did not require an isogravimetric state for its determination. These data suggest that the major sites of filtration and vascular capacitance in the pulmonary circulation reside in the microvessels and that the more easily determined Pcv is an adequate measure of the average capillary filtration pressure in the lungs.

This article has been cited by other articles:

				S. A. Barman Effect of protein kinase C inhibition on hypoxic pulmonary vasoconstriction Am J Physiol Lung Cell Mol Physiol, May 1, 2001; 280(5): L888 - L895. [Abstract] [Full Text] [PDF]

				S. A. Barman Potassium channels modulate canine pulmonary vasoreactivity to protein kinase C activation Am J Physiol Lung Cell Mol Physiol, September 1, 1999; 277(3): L558 - L565. [Abstract] [Full Text] [PDF]

				S. A. Barman Potassium channels modulate hypoxic pulmonary vasoconstriction Am J Physiol Lung Cell Mol Physiol, July 1, 1998; 275(1): L64 - L70. [Abstract] [Full Text] [PDF]

				S. A. Barman Pulmonary vasoreactivity to serotonin during hypoxia is modulated by ATP-sensitive potassium channels J Appl Physiol, August 1, 1997; 83(2): 569 - 574. [Abstract] [Full Text] [PDF]