Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 55: 413-418, 1983;
8750-7587/83 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Milledge, J. S.
Right arrow Articles by Minty, B. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Milledge, J. S.
Right arrow Articles by Minty, B. D.

Journal of Applied Physiology, Vol 55, Issue 2 413-418, Copyright © 1983 by American Physiological Society

ARTICLES

Effect of prolonged exercise at altitude on the renin-aldosterone system

J. S. Milledge, D. M. Catley, E. S. Williams, W. R. Withey and B. D. Minty

The combined effect of exercise and altitude on the renin-aldosterone system was studied in six male subjects on a fixed diet. After 4 control days at rest and at low altitude, subjects ascended to 3,100 m and took about 7 h exercise daily for 5 days. There followed a 4-day recovery period at low altitude. Daily blood samples were taken for estimation of plasma renin activity (PRA), plasma aldosterone concentration (PAC), and angiotensin converting-enzyme (ACE) activity. Results showed a maximal rise in PRA and PAC with exercise at altitude maximal on the first 2 days. ACE activity fell by 23% at altitude. Compared with similar exercise at sea level, the rise in PAC was comparable but the rise in PRA was four times greater, indicating a marked decrease in PAC response to PRA. It is suggested that this loss of sensitivity of PAC to PRA is mediated by the measured reduction in ACE activity.


This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
D. R. Woods, A. J. Pollard, D. J. Collier, Y. Jamshidi, V. Vassiliou, E. Hawe, S. E. Humphries, and H. E. Montgomery
Insertion/Deletion Polymorphism of the Angiotensin I-Converting Enzyme Gene and Arterial Oxygen Saturation at High Altitude
Am. J. Respir. Crit. Care Med., August 1, 2002; 166(3): 362 - 366.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. Imoberdorf, P. J. Garlick, M. A. McNurlan, G. A. Casella, E. Peheim, M. Turgay, P. Bartsch, and P. E. Ballmer
Enhanced synthesis of albumin and fibrinogen at high altitude
J Appl Physiol, February 1, 2001; 90(2): 528 - 537.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online