Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 55: 92-99, 1983;
8750-7587/83 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hinson, J. M.
Right arrow Articles by Snapper, J. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hinson, J. M., Jr
Right arrow Articles by Snapper, J. R.

Journal of Applied Physiology, Vol 55, Issue 1 92-99, Copyright © 1983 by American Physiological Society

ARTICLES

Effect of granulocyte depletion on altered lung mechanics after endotoxemia in sheep

J. M. Hinson Jr, A. A. Hutchison, M. L. Ogletree, K. L. Brigham and J. R. Snapper

To examine the role of circulating granulocytes in the airway changes caused by endotoxemia, we measured the response of chronically instrumented unanesthetized sheep to endotoxemia before and after granulocyte depletion with hydroxyurea. Granulocyte depletion did not affect the increases in mean pulmonary arterial pressure caused by endotoxin [peak pressure 59 +/- 8 cmH2O +/- (SE) control, 51 +/- 8 cmH2O granulocyte depleted]. However, the early (30-60 min after endotoxin) airway response to endotoxemia was markedly attenuated. Without granulocyte depletion, endotoxin caused dynamic compliance (Cdyn) to decrease to 41 +/- 10% of the base-line value and total lung resistance (RL) to increase to 283 +/- 61% of base line. When animals were granulocyte depleted, endotoxin decreased Cdyn to 69 +/- 6% (P less than 0.05) of base line and increased RL to 141 +/- 20% of base line (P less than 0.05). Granulocyte depletion also attenuated the effect of endotoxin on arterial oxygenation. During the maximum airway response to endotoxin, the alveolar-to-arterial oxygen gradient was 47 +/- 5 Torr in control studies and 32 +/- 2 Torr in granulocyte depleted studies (P less than 0.05). We conclude that interaction of granulocytes with the lung contributes to the changes in lung mechanics observed following endotoxemia and that the early pulmonary hypertension and the early alterations in lung mechanics caused by endotoxemia are caused by separate processes.


This article has been cited by other articles:


Home page
 Eur Respir JHome page
E.D. Moloney and T.W. Evans
Pathophysiology and pharmacological treatment of pulmonary hypertension in acute respiratory distress syndrome
Eur. Respir. J., April 1, 2003; 21(4): 720 - 727.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. WOLLIN, S. UHLIG, R. NÜSING, and A. WENDEL
Granulocyte-Macrophage Colony-Stimulating Factor Amplifies Lipopolysaccharide-induced Bronchoconstriction by a Neutrophil- and Cyclooxygenase 2-Dependent Mechanism
Am. J. Respir. Crit. Care Med., February 1, 2001; 163(2): 443 - 450.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
H.-P. KUO, H.-C. LIN, K.-H. HWANG, C.-H. WANG, and L.-C. LU
Lipopolysaccharide Enhances Substance P-mediated Neutrophil Adherence to Epithelial Cells and Cytokine Release
Am. J. Respir. Crit. Care Med., November 1, 2000; 162(5): 1891 - 1897.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
L. Mark and E. P. Ingenito
Surfactant function and composition after free radical exposure generated by transition metals
Am J Physiol Lung Cell Mol Physiol, March 1, 1999; 276(3): L491 - L500.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online