| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Applied Physiology, Vol 54, Issue 6 1635-1640, Copyright © 1983 by American Physiological Society
ARTICLES |
G. A. Farkas and C. Roussos
We investigated whether the shift in the diaphragmatic length-tension curve of emphysematous animals was due to changes in either sarcomere number or sarcomere length. In vitro length-tension characteristics of the diaphragm were evaluated in control and emphysematous hamsters. Emphysema was induced by a single endotracheal instillation of elastase. Functional residual capacity, measured by means of a plethysmograph, was about twice that measured in emphysematous animals compared with control animals. Small diaphragmatic bundles were isolated and evaluated for their length-tension characteristics. The length-tension curve of diaphragms from emphysematous animals was displaced toward the left. Maximal tetanic tensions were similar in both groups, whereas optimal bundle length was significantly decreased in the emphysematous animals. Sarcomere number and sarcomere length at optimal length were then calculated for the diaphragmatic bundles. The bundles from emphysematous animals were found to have a significantly reduced number of sarcomeres, as well as a significantly decreased sarcomere length at optimal compared with control values. The total number of sarcomeres were also found to be significantly negatively correlated with the animal's functional residual capacity. From these results, we conclude that the decrease in diaphragmatic length, seen with hyperinflation, is due mainly to a loss of sarcomeres and possibly to a small decrease in sarcomere length measured at optimal bundle length.
This article has been cited by other articles:
|
|
 |
|
  D. Leduc and A. De Troyer Dysfunction of the canine respiratory muscle pump in ascites J Appl Physiol, February 1, 2007; 102(2): 650 - 657. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Moore, A. Stubbings, E. B. Swallow, M. Dusmet, P. Goldstraw, R. Porcher, J. Moxham, M. I. Polkey, and M. A. Ferenczi Passive properties of the diaphragm in COPD J Appl Physiol, November 1, 2006; 101(5): 1400 - 1405. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. De Troyer and D. Leduc Effects of single-lung inflation on inspiratory muscle function in dogs J. Physiol., October 1, 2006; 576(1): 269 - 277. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Leduc and A. D. Troyer The effect of lung inflation on the inspiratory action of the canine parasternal intercostals J Appl Physiol, March 1, 2006; 100(3): 858 - 863. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. R. Bai, J. H. T. Bates, V. Brusasco, B. Camoretti-Mercado, P. Chitano, L. H. Deng, M. Dowell, B. Fabry, L. E. Ford, J. J. Fredberg, et al. On the terminology for describing the length-force relationship and its changes in airway smooth muscle J Appl Physiol, December 1, 2004; 97(6): 2029 - 2034. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. I. Lewis, M. Fournier, X. Da, H. Li, Z. Mosenifar, R. J. McKenna Jr, and A. H. Cohen Short-term Influences of Lung Volume Reduction Surgery on the Diaphragm in Emphysematous Hamsters Am. J. Respir. Crit. Care Med., October 1, 2004; 170(7): 753 - 759. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Vassilakopoulos and B. J. Petrof Ventilator-induced Diaphragmatic Dysfunction Am. J. Respir. Crit. Care Med., February 1, 2004; 169(3): 336 - 341. [Full Text] [PDF]
|
|
|
|
 |
|
 F. Chen, M. Nakai, A. Aoyama, N. Isowa, and K. Chihara Diaphragmatic elevation of a patient with chronic obstructive pulmonary disease after left upper lobectomy Interactive CardioVascular and Thoracic Surgery, December 1, 2003; 2(4): 688 - 691. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Laghi and M. J. Tobin Disorders of the Respiratory Muscles Am. J. Respir. Crit. Care Med., July 1, 2003; 168(1): 10 - 48. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. B. Gorman, D. K. McKenzie, N. B. Pride, J. F. Tolman, and S. C. Gandevia Diaphragm Length during Tidal Breathing in Patients with Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., December 1, 2002; 166(11): 1461 - 1469. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Yang, J. Luo, J. Bourdon, M.-C. Lin, S. B. Gottfried, and B. J. Petrof Controlled Mechanical Ventilation Leads to Remodeling of the Rat Diaphragm Am. J. Respir. Crit. Care Med., October 15, 2002; 166(8): 1135 - 1140. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
ATS/ERS Statement on Respiratory Muscle Testing Am. J. Respir. Crit. Care Med., August 15, 2002; 166(4): 518 - 624. [Full Text] [PDF]
|
|
|
|
 |
|
 F. Bellemare, M.-P. Cordeau, J. Couture, E. Lafontaine, P. Leblanc, and L. Passerini Effects of Emphysema and Lung Volume Reduction Surgery on Transdiaphragmatic Pressure and Diaphragm Length* Chest, June 1, 2002; 121(6): 1898 - 1910. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Levine, C. Gregory, T. Nguyen, J. Shrager, L. Kaiser, N. Rubinstein, and G. Dudley Bioenergetic adaptation of individual human diaphragmatic myofibers to severe COPD J Appl Physiol, March 1, 2002; 92(3): 1205 - 1213. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Shrager, D.-K. Kim, Y. J. Hashmi, H. H. Stedman, J. Zhu, L. R. Kaiser, and S. Levine Sarcomeres Are Added in Series to Emphysematous Rat Diaphragm After Lung Volume Reduction Surgery Chest, January 1, 2002; 121(1): 210 - 215. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-H. Kuo, L. Wang, P. D. Pare, L. E. Ford, and C. Y. Seow Myosin thick filament lability induced by mechanical strain in airway smooth muscle J Appl Physiol, May 1, 2001; 90(5): 1811 - 1816. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. C. POOLE, C. A. KINDIG, and B. J. BEHNKE Effects of Emphysema on Diaphragm Microvascular Oxygen Pressure Am. J. Respir. Crit. Care Med., April 1, 2001; 163(5): 1081 - 1086. [Abstract] [Full Text]
|
|
|
|
|
|
L. Wang, P. D. Pare, and C. Y. Seow Plasticity in Skeletal, Cardiac, and Smooth Muscle: Selected Contribution: Effect of chronic passive length change on airway smooth muscle length-tension relationship J Appl Physiol, February 1, 2001; 90(2): 734 - 740. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. Shrager, D.-K. Kim, Y. J. Hashmi, E. B. Lankford, P. Wahl, H. H. Stedman, S. Levine, and L. R. Kaiser Lung volume reduction surgery restores the normal diaphragmatic length-tension relationship in emphysematous rats J. Thorac. Cardiovasc. Surg., February 1, 2001; 121(2): 0217 - 224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Baydur Improvements in Lung and Respiratory Muscle Function Following Lung Volume Reduction Surgery : Smaller May Be Better, But How Long Does It Last? Chest, December 1, 1999; 116(6): 1507 - 1509. [Full Text] [PDF]
|
|
|
|
|
|
W. L. Sexton and D. C. Poole Effects of emphysema on diaphragm blood flow during exercise J Appl Physiol, March 1, 1998; 84(3): 971 - 979. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. C. Poole and O. Mathieu-Costello Effect of pulmonary emphysema on diaphragm capillary geometry J Appl Physiol, February 1, 1997; 82(2): 599 - 606. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
