Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 54: 934-942, 1983;
8750-7587/83 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Stirling, D. R.
Right arrow Articles by Dosman, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stirling, D. R.
Right arrow Articles by Dosman, J. A.

Journal of Applied Physiology, Vol 54, Issue 4 934-942, Copyright © 1983 by American Physiological Society

ARTICLES

Characteristics of airway tone during exercise in patients with asthma

D. R. Stirling, D. J. Cotton, B. L. Graham, W. C. Hodgson, D. W. Cockcroft and J. A. Dosman

In 10 nonasthmatic subjects and 11 patients with asthma, we measured pulmonary resistance (RL), functional residual capacity (FRC), and specific conductance (sGaw) before, during, and after submaximal treadmill exercise. Nonasthmatic subjects did not change RL, FRC, or sGaw from base-line resting values during or after exercise. In patients with asthma, RL decreased significantly during exercise, both when exercise was begun from the control resting state and from conditions of elevated RL after a preceding period of exercise. When asthmatic patients inhaled a standardized dose of aerosolized histamine, the increase in RL during exercise was significantly less than the increase in RL when they breathed histamine at rest. When patients hyperventilated at rest with tidal volumes, breathing frequencies, and end-tidal CO2 tensions similar to those during exercise conditions, bronchodilatation also occurred, and the increase in RL following inhaled histamine during isocapnic hyperventilation was also less than at rest. Since bronchodilatation and inhibition of histamine-induced bronchoconstriction occur during both exercise and isocapnic hyperventilation, we suggest that the mechanism of bronchodilatation during exercise may not necessarily be related to metabolic factors associated with exercise.


This article has been cited by other articles:


Home page
 Proc Am Thorac SocHome page
R. W. Mitchell, M. L. Dowell, J. Solway, and O. J. Lakser
Force Fluctuation induced Relengthening of Acetylcholine-contracted Airway Smooth Muscle
Proceedings of the ATS, January 1, 2008; 5(1): 68 - 72.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H. C. Haverkamp, J. A. Dempsey, J. D. Miller, L. M. Romer, D. F. Pegelow, A. T. Lovering, and M. W. Eldridge
Repeat exercise normalizes the gas-exchange impairment induced by a previous exercise bout in asthmatic subjects
J Appl Physiol, November 1, 2005; 99(5): 1843 - 1852.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H. C. Haverkamp, J. A. Dempsey, J. D. Miller, L. M. Romer, D. F. Pegelow, J. R. Rodman, and M. W. Eldridge
Gas exchange during exercise in habitually active asthmatic subjects
J Appl Physiol, November 1, 2005; 99(5): 1938 - 1950.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. L. Dowell, O. J. Lakser, W. T. Gerthoffer, J. J. Fredberg, G. L. Stelmack, A. J. Halayko, J. Solway, and R. W. Mitchell
Latrunculin B increases force fluctuation-induced relengthening of ACh-contracted, isotonically shortened canine tracheal smooth muscle
J Appl Physiol, February 1, 2005; 98(2): 489 - 497.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. Corsico, P. Fulgoni, M. Beccaria, M. C. Zoia, G. Barisione, R. Pellegrino, V. Brusasco, and I. Cerveri
Effects of exercise and beta 2-agonists on lung function in chronic obstructive pulmonary disease
J Appl Physiol, December 1, 2002; 93(6): 2053 - 2058.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. A. Fontana, T. Pantaleo, F. Lavorini, F. Bongianni, M. Mannelli, P. D. Bridge, and M. Pistolesi
Handgrip-induced airway dilation in asthmatic patients with bronchoconstriction induced by MCh inhalation
J Appl Physiol, November 1, 2002; 93(5): 1723 - 1730.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
E. Crimi, R. Pellegrino, A. Smeraldi, and V. Brusasco
Exercise-induced bronchodilation in natural and induced asthma: effects on ventilatory response and performance
J Appl Physiol, June 1, 2002; 92(6): 2353 - 2360.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
O. E. Suman and K. C. Beck
Role of nitric oxide during hyperventilation-induced bronchoconstriction in the guinea pig
J Appl Physiol, April 1, 2001; 90(4): 1474 - 1480.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
O. E. Suman, J. D. Morrow, K. A. O'Malley, and K. C. Beck
Airway function after cyclooxygenase inhibition during hyperpnea-induced bronchoconstriction in guinea pigs
J Appl Physiol, November 1, 2000; 89(5): 1971 - 1978.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
O. E. Suman, K. C. Beck, M. A. Babcock, D. F. Pegelow, and W. G. Reddan
Airway obstruction during exercise and isocapnic hyperventilation in asthmatic subjects
J Appl Physiol, September 1, 1999; 87(3): 1107 - 1113.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. C. Beck, R. E. Hyatt, P. Mpougas, and P. D. Scanlon
Evaluation of pulmonary resistance and maximal expiratory flow measurements during exercise in humans
J Appl Physiol, April 1, 1999; 86(4): 1388 - 1395.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online