Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 54: 730-739, 1983;
8750-7587/83 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hazucha, M. J.
Right arrow Articles by Bromberg, P. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hazucha, M. J.
Right arrow Articles by Bromberg, P. A.

Journal of Applied Physiology, Vol 54, Issue 3 730-739, Copyright © 1983 by American Physiological Society

ARTICLES

Effects of 0.1 ppm nitrogen dioxide on airways of normal and asthmatic subjects

M. J. Hazucha, J. F. Ginsberg, W. F. McDonnell, E. D. Haak Jr, R. L. Pimmel, S. A. Salaam, D. E. House and P. A. Bromberg

It has been reported (J. Clin. Invest. 57: 301-307, 1976) that inhalation of nitrogen dioxide (NO2) will enhance the bronchial reactivity of asthmatics. This study was designed to evaluate the respiratory effect of a 1-h exposure of normal subjects and of atopic asthmatics to 0.1 parts per million (ppm) NO2. Fifteen normal and 15 asthmatic subjects were exposed to air and to NO2 in a randomized double-blind crossover design. Exposure to either atmosphere was bracketed by bronchial inhalation challenge using aerosolized metacholine chloride solutions. Plethysmographic measurements of specific airway resistance (sRaw) and the forced random noise impedance spectrum (5-30 Hz) were obtained immediately after each methacholine dose. Following acute exposure to NO2, there was a slight but not significant increase in mean base-line sRaw in both normals and asthmatics. The overall base-line resistive properties of the respiratory system determined by forced random noise excitation were not significantly affected by NO2 inhalation either. Finally, there was no change in bronchial response to methacholine challenge in either group. These findings indicate that 0.1 ppm NO2 exposure for 1 h without exercise had no demonstrable airways effects in either young atopic asthmatics with mild disease or young normal subjects.


This article has been cited by other articles:


Home page
 Eur Respir JHome page
G. D'Amato, G. Liccardi, M. D'Amato, and M. Cazzola
Outdoor air pollution, climatic changes and allergic bronchial asthma
Eur. Respir. J., September 1, 2002; 20(3): 763 - 776.
[Abstract] [Full Text] [PDF]

Home page
 Occup. Environ. Med.Home page
T W Pelham, L E Holt, and M A Moss
Exposure to carbon monoxide and nitrogen dioxide in enclosed ice arenas
Occup. Environ. Med., April 1, 2002; 59(4): 224 - 233.
[Abstract] [Full Text] [PDF]

Home page
 Indoor and Built EnvironmentHome page
J. Strom, L. Alfredsson, T. Malmfors, and O. Selroos
Review : Nitrogen Dioxide: Causation and Aggravation of Lung Diseases
Indoor and Built Environment, March 1, 1994; 3(2): 58 - 68.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online