Journal of Applied Physiology Journal of Applied Physiology
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J Appl Physiol 54: 571-575, 1983;
8750-7587/83 $5.00
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Journal of Applied Physiology, Vol 54, Issue 2 571-575, Copyright © 1983 by American Physiological Society

ARTICLES

Effects of stopping training on size and response to insulin of fat cells in female rats

B. W. Craig, K. Thompson and J. O. Holloszy

The parametrial adipocytes of exercise-trained female rats were smaller and had greater rates of 2-deoxyglucose uptake and glucose oxidation over a wide range of insulin concentrations than the fat cells of sedentary animals of the same age. The fat cells of the sedentary animals had a 180% greater volume than those of the trained rats, despite only a 9% difference in body weight. Following cessation of training adipocyte size increased rapidly; approximately two-thirds of the initial difference in fat cell volume between the trained and sedentary rats had disappeared after 9 days without exercise. Concomitant with the increase in fat cell size, the response of 2-deoxyglucose uptake and glucose oxidation to insulin diminished. There was a close correlation between fat cell size and the magnitude of the response to insulin of both glucose oxidation and 2-deoxyglucose uptake. It appears from these results that the effect of exercise training on the response of adipocytes to insulin is rapidly lost when exercise is stopped.


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