Journal of Applied Physiology AJP: Advances in Physiology Education
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 54: 24-30, 1983;
8750-7587/83 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Block, E. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Block, E. R.

Journal of Applied Physiology, Vol 54, Issue 1 24-30, Copyright © 1983 by American Physiological Society

ARTICLES

Endotoxin protects against hyperoxic alterations in lung endothelial cell metabolism

E. R. Block

By evaluating the ability of endotoxin to prevent hyperoxic depressions in lung amine uptake, this study assessed whether bacterial endotoxin protects against hyperoxic injury to the pulmonary endothelium. Rats were given 500 or 1,500 micrograms/kg body wt of endotoxin or saline (controls) 30 min before a 24-h or 7-day exposure to air or 100% O2 at 1 ATA. Immediately after exposure, lungs were isolated, ventilated, and perfused via the pulmonary artery and the uptake of two amines, [14C] serotonin and [3H]norepinephrine, was measured. Amine uptake by the lungs of control rats exposed to 100% O2 for 24 h was significantly depressed, whereas amine uptake by the lungs of endotoxin-treated rats exposed to 100% O2 for 24 h was comparable to that in air-exposed controls. Endotoxin also prevented hyperoxic depression of lung amine uptake and prolonged survival in rats exposed to 100% O2 for 7 days. Pretreatment of rats with endotoxin protects against hyperoxic injury to the pulmonary endothelium, which may account for the reduced mortality in endotoxin-treated animals.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. Kohno, A. Ishizaka, M. Sawafuji, H. Koh, Y. Hirayama, E. Ikeda, T. Shiomi, A. Ohashi, Y. Okada, and K. Kobayashi
Hyperoxia-induced emphysematous changes in subacute phase of endotoxin-induced lung injury in rats
Am J Physiol Lung Cell Mol Physiol, July 1, 2004; 287(1): L184 - L190.
[Abstract] [Full Text] [PDF]

Home page
 J Intensive Care MedHome page
S. G. Jenkinson
Analytic Reviews : Oxygen Toxicity
J Intensive Care Med, May 1, 1988; 3(3): 137 - 152.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online