Journal of Applied Physiology, Vol 53, Issue 5 1256-1262, Copyright © 1982 by American Physiological Society
CO2 elimination by high-frequency oscillations in dogs--effects of histamine infusion
T. H. Rossing, A. S. Slutsky, R. H. Ingram Jr, R. D. Kamm, A. H. Shapiro and J. M. Drazen
Effective gas exchange can be achieved in normal dogs by ventilation at
frequencies of 4-20 Hz using stroke volumes (SV) smaller than the anatomic
dead space. CO2 elimination is largely a function of tracheal SV-frequency
product (Vosc) in anesthetized, paralyzed dogs with normal lungs. To
determine the effect of constriction of small airways on gas exchange
during such high-frequency ventilation (HFV), we ventilated five
anesthetized, paralyzed, and vagotomized dogs via a tracheal cannula before
and during intravenous histamine infusion. Vosc was varied by varying the
frequency while keeping SV constant. For low Vosc, CO2 elimination (VCO2)
increased directly with Vosc during control and histamine experiments. At
high Vosc, VCO2 continued to increase directly with Vosc during the control
study, but during histamine infusion VCO2 was lower than control values.
Eucapnia could be maintained in each dog during HFV, even during airway
constriction. During histamine infusion the frequency-dependent mechanical
properties of the lung influence the delivery of the HFV SV to the
respiratory zone, and this may explain the lower VCO2 observed.
