Journal of Applied Physiology AJP: Endocrinology and Metabolism
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 53: 475-482, 1982;
8750-7587/82 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Frank, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Frank, L.

Journal of Applied Physiology, Vol 53, Issue 2 475-482, Copyright © 1982 by American Physiological Society

ARTICLES

Protection from O2 toxicity by preexposure to hypoxia: lung antioxidant enzyme role

L. Frank

Adult rats preexposed to 10% O2 for 3 days had marked tolerance to hyperoxia-induced lung damage and lethality. The survival of preexposed vs. nonpreexposed rats at 72 h of hyperoxic exposure was 62/62 vs. 7/47 (15%), P less than 0.0001; and after 7 days in 96-98% O2, the comparative survival was 31/33 (94%) vs. 1/20 (5%), P less than 0.0005. Hypoxic exposure produced significant elevations in rat lung superoxide dismutase, catalase, glutathione peroxidase, and glucose-6-phosphate dehydrogenase activities. In contrast, in adult mice and hamsters, no increased lung antioxidant enzyme levels were produced by preexposure to hypoxia and no significant tolerance to high O2 was realized. (Lethal time50 values for hypoxia-preexposed and nonpreexposed mice, 5.2 and 4.4 days, respectively; and for hamsters, 6.4 and 6.1 days, respectively.) Thus the protective effect of hypoxic preexposure is correlated with adaptive changes in lung antioxidant enzyme activity. Evidence in the literature suggests that superoxide anion (O-2) and H2O2 production may increase under hypoxic conditions. Increased cellular concentrations of their normal substrates could stimulate antioxidant enzyme rises during the preexposure period in hypoxia.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. E. Turley, L. D. Nelin, M. R. Kaplowitz, Y. Zhang, and C. D. Fike
Exhaled NO is reduced at an early stage of hypoxia-induced pulmonary hypertension in newborn piglets
Am J Physiol Lung Cell Mol Physiol, March 1, 2003; 284(3): L489 - L500.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
S. Ahmad, A. Ahmad, E. Gerasimovskaya, K. R. Stenmark, C. B. Allen, and C. W. White
Hypoxia Protects Human Lung Microvascular Endothelial and Epithelial-like Cells against Oxygen Toxicity: Role of Phosphatidylinositol 3-Kinase
Am. J. Respir. Cell Mol. Biol., February 1, 2003; 28(2): 179 - 187.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. S. Carraway, A. J. Ghio, J. D. Carter, and C. A. Piantadosi
Expression of heme oxygenase-1 in the lung in chronic hypoxia
Am J Physiol Lung Cell Mol Physiol, April 1, 2000; 278(4): L806 - L812.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. R. Riddle, A. Ahmad, S. Ahmad, S. S. Deeb, M. Malkki, B. K. Schneider, C. B. Allen, and C. W. White
Hypoxia induces hexokinase II gene expression in human lung cell line A549
Am J Physiol Lung Cell Mol Physiol, February 1, 2000; 278(2): L407 - L416.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
L.-W. Chen, C.-F. Chen, and Y.-L. Lai
Chronic activation of neurokinin-1 receptor induces pulmonary hypertension in rats
Am J Physiol Heart Circ Physiol, May 1, 1999; 276(5): H1543 - H1551.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online