Journal of Applied Physiology
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J Appl Physiol 52: 1552-1556, 1982;
8750-7587/82 $5.00
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Journal of Applied Physiology, Vol 52, Issue 6 1552-1556, Copyright © 1982 by American Physiological Society

ARTICLES

Effects of horizontal body casting on the baroreceptor reflex control of heart rate

G. E. Billman, D. T. Dickey, H. Sandler and H. L. Stone

The purpose of this study was to investigate the effects of long-term horizontal body position on baroreceptor reflex control of heart rate. Six male rhesus monkeys (6.2-9.4 kg) were given bolus injections of 4.0 micrograms/kg phenylephrine during each of the following conditions: awake, anesthetized (10 mg/kg ketamine HCl), and after beta-blockade (1 mg/kg propranolol HCl) before, 7, 14, and 28 days after being placed in a horizontal body cast. R-R interval vs. systolic arterial pressure was plotted, and the slope was determined by least-squares-fit linear regression. Baroreceptor slope was significantly reduced by 7 days of horizontal body position and remained attenuated throughout the 28-day restraint period both before and after beta-receptor blockade. These data are consistent with the thesis that prolonged exposure to a zero-gravity environment impairs autonomic reflex regulation of the cardiovascular system.


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