Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 52: 1453-1457, 1982;
8750-7587/82 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Morrison, S. C.
Right arrow Articles by Campbell, E. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Morrison, S. C.
Right arrow Articles by Campbell, E. J.

Journal of Applied Physiology, Vol 52, Issue 6 1453-1457, Copyright © 1982 by American Physiological Society

ARTICLES

Lung volume, closing volume, and gas exchange

S. C. Morrison, D. G. Stubbing, P. V. Zimmerman and E. J. Campbell

The effect of a voluntary reduction in lung volume on arterial O2 saturation (SaO2) was studied in 10 normal subjects aged 19-63 yr. SaO2 was measured by ear oximetry first during tidal breathing at functional residual capacity, and then during tidal breathing at 380 ml above residual volume. Tidal volume and breathing frequency were kept constant, and end-tidal CO2 partial pressure remained stable or fell in 9 out of 10 subjects. When lung volume was reduced, SaO2 fell by a mean of 1.5% (range 0-3%). Closing volume (CV) was measured by the N2-washout method (mean 0.89 liter, range 0.41-1.44). There was a close correlation between CV and the fall in SaO2 (r = 0.867, P = 0.001). Arterial and mixed venous CO2 were measured in one subject; the results indicated some fall in cardiac output following the lung volume change, but this accounted for less than half of the fall in SaO2. The relationship between CV and the lung volume at which tidal breathing occurs is an important determinant of pulmonary gas exchange through its effect on the matching of ventilation to perfusion.


This article has been cited by other articles:


Home page
 Br J AnaesthHome page
G. B. Drummond and J. Milic-Emili
Forty years of closing volume
Br. J. Anaesth., December 1, 2007; 99(6): 772 - 774.
[Full Text] [PDF]

Home page
 Br J AnaesthHome page
G. B. Drummond
The abdominal muscles in anaesthesia and after surgery
Br. J. Anaesth., July 1, 2003; 91(1): 73 - 80.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online