Journal of Applied Physiology
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J Appl Physiol 52: 607-614, 1982;
8750-7587/82 $5.00
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Journal of Applied Physiology, Vol 52, Issue 3 607-614, Copyright © 1982 by American Physiological Society

ARTICLES

Ventilatory adaptations to resistive loading during wakefulness and non-REM sleep

C. Iber, A. Berssenbrugge, J. B. Skatrud and J. A. Dempsey

Ventilatory and timing responses to repetitive and sustained inspiratory resistive loading were assessed in six naive male subjects during wakefulness (AW) and non-REM sleep (NREM). In five of six subjects, tidal volume (VT) was maintained or increased with repetitive five-breath loading periods during wakefulness. In these five subjects, mouth occlusion pressure (P100) increased with loading during AW (1.8 +/- 0.5 control vs. 2.2 +/- 0.4 cmH2O loaded, P less than 0.05), but not during NREM (2.1 +/- 1.5 control vs. 2.1 + 1.5 cmH2O loaded). For each state, VT and frequency (f) responses to sustained loads were similar to responses to five-breath loads. During sustained loading; a) VT increased 35% during AW, decreased 28% during NREM, b) f decreased 35% during AW, increased 6% during NREM, c) minute ventilation (VE) decreased 12% during AW, decreased 23% during NREM. Ventilatory responses persisted until arousal (0.4--1.7 min) in NREM. With repetitive loading: a) inspiratory duration (TI) increased during AW but did not change during NREM, b) "duty cycle" (TI/TT) increased with loading in both states. These findings suggest that a) NREM abolishes between-breath augmentations in P100, b) within-breath load compensation is operant during both AW (preserved VT) and NREM (failure of predicted TI prolongation) by differing mechanisms, c) arousal may be a ventilatory compensation to inspiratory resistive loading in NREM.


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