| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Applied Physiology, Vol 52, Issue 3 537-542, Copyright © 1982 by American Physiological Society
ARTICLES |
Y. Kawakami, T. Yoshikawa, A. Shida, Y. Asanuma and M. Murao
To clarify the role of genetics in determining chemical and behavioral control of breathing, an age-, body size-, and sex ratio-matched study was conducted in 62 twins (mean age 16.4 yr, 20 pairs of monozygotic twins (MZ) and 11 pairs of dizygotic twins (DZ)] for ventilatory responses to hypoxia (A) and hypercapnia (S) along with thresholds for perception of added inspiratory resistance. A and S were determined by a dual-control system developed to regulate arterial blood gases at predetermined levels. Mean values for A, S, thresholds for added resistance, and mouth pressure at the threshold were not different between MZ and DZ. Within-pair variances for A, S, and mouth pressure at the threshold were significantly smaller in MZ than DZ. Neither A nor S correlated with thresholds for resistance and mouth pressure in either MZ or DZ. These results indicate that in adolescent twins sensitivity to added inspiratory resistance and chemosensitivity to hypoxia and hypercapnia involve genetically determined factors, and perception of added inspiratory resistance is not directly related to chemical control of breathing.
This article has been cited by other articles:
|
|
 |
|
  J. T. S. Brooks, G. P. Elvidge, L. Glenny, J. M. Gleadle, C. Liu, J. Ragoussis, T. G. Smith, N. P. Talbot, L. Winchester, P. H. Maxwell, et al. Variations within oxygen-regulated gene expression in humans J Appl Physiol, January 1, 2009; 106(1): 212 - 220. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Balbir, H. Lee, M. Okumura, S. Biswal, R. S. Fitzgerald, and M. Shirahata A search for genes that may confer divergent morphology and function in the carotid body between two strains of mice Am J Physiol Lung Cell Mol Physiol, March 1, 2007; 292(3): L704 - L715. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Xu, J. Zhuang, T. Zhou, and L.-Y. Lee Ovalbumin sensitization alters the ventilatory responses to chemical challenges in guinea pigs J Appl Physiol, November 1, 2005; 99(5): 1782 - 1788. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Yamaguchi, A. Balbir, B. Schofield, J. Coram, C. G. Tankersley, R. S. Fitzgerald, C. P. O'Donnell, and M. Shirahata Structural and functional differences of the carotid body between DBA/2J and A/J strains of mice J Appl Physiol, April 1, 2003; 94(4): 1536 - 1542. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Garcia-Rio, J.M. Pino, T. Ramirez, D. Alvaro, A. Alonso, C. Villasante, and J. Villamor Inspiratory neural drive response to hypoxia adequately estimates peripheral chemosensitivity in OSAHS patients Eur. Respir. J., September 1, 2002; 20(3): 724 - 732. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Hodges, H. V. Forster, P. E. Papanek, M. R. Dwinell, and G. E. Hogan Ventilatory phenotypes among four strains of adult rats J Appl Physiol, September 1, 2002; 93(3): 974 - 983. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Gorman, J. Kent, J. Martinez, S. Browne, J. Coplan, and L. A. Papp Physiological Changes During Carbon Dioxide Inhalation in Patients With Panic Disorder, Major Depression, and Premenstrual Dysphoric Disorder: Evidence for a Central Fear Mechanism Arch Gen Psychiatry, February 1, 2001; 58(2): 125 - 131. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. D. FULLER, T. L. BAKER, M. BEHAN, and G. S. MITCHELL Expression of hypoglossal long-term facilitation differs between substrains of Sprague-Dawley rat Physiol Genomics, January 19, 2001; 4(3): 175 - 181. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R Jokic, T Zintel, G Sridhar, C G Gallagher, and M F Fitzpatrick Ventilatory responses to hypercapnia and hypoxia in relatives of patients with the obesity hypoventilation syndrome Thorax, November 1, 2000; 55(11): 940 - 945. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. M. Marin, M. Montes de Oca, J. Rassulo, and B. R. Celli Ventilatory Drive at Rest and Perception of Exertional Dyspnea in Severe COPD Chest, May 1, 1999; 115(5): 1293 - 1300. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. AIDA, K. MIYAMOTO, M. NISHIMURA, M. AIBA, S. KIRA, Y. KAWAKAMI, and the Respiratory Failure Research Group in Japan Prognostic Value of Hypercapnia in Patients with Chronic Respiratory Failure during Long-term Oxygen Therapy Am. J. Respir. Crit. Care Med., July 1, 1998; 158(1): 188 - 193. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. V. Weil, T. Stevens, C. K. Pickett, K. Tatsumi, M. G. Dickinson, C. R. Jacoby, and D. M. Rodman Strain-associated differences in hypoxic chemosensitivity of the carotid body in rats Am J Physiol Lung Cell Mol Physiol, May 1, 1998; 274(5): L767 - L774. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S. Curran, J. Zhuang, S. F. Sun, and L. G. Moore Ventilation and hypoxic ventilatory responsiveness in Chinese-Tibetan residents at 3,658 m J Appl Physiol, December 1, 1997; 83(6): 2098 - 2104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. P. Strohl, A. J. Thomas, P. St. Jean, E. H. Schlenker, R. J. Koletsky, and N. J. Schork Ventilation and metabolism among rat strains J Appl Physiol, January 1, 1997; 82(1): 317 - 323. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Kikuchi, S. Okabe, G. Tamura, W. Hida, M. Homma, K. Shirato, and T. Takishima Chemosensitivity and Perception of Dyspnea in Patients with a History of Near-Fatal Asthma N. Engl. J. Med., May 12, 1994; 330(19): 1329 - 1334. [Abstract] [Full Text]
|
|
|
|
|
|
R. R. Goetz, D. F. Klein, R. Gully, J. Kahn, M. R. Liebowitz, A. J. Fyer, and J. M. Gorman Panic Attacks During Placebo Procedures in the Laboratory: Physiology and Symptomatology Arch Gen Psychiatry, April 1, 1993; 50(4): 280 - 285. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
