Journal of Applied Physiology, Vol 51, Issue 6 1618-1624, Copyright © 1981 by American Physiological Society
Denervated and intact kidney responses to exercise in the dog
J. Sadowski, R. Gellert, J. Kurkus and E. Portalaska
In conscious female dogs exercise-induced changes in the function of the
innervated and denervated kidney were studied by clearance techniques. The
animals were prepared for experiments by chronic unilateral renal
denervation and surgical division of the urinary bladder to enable separate
urine collection from each kidney. A 20-min run on a treadmill at a speed
of 2.6 m/s significantly decreased urine flow, osmolar clearance, sodium
excretion, as well as clearances of exogenous creatinine and
p-aminohippurate in the denervated kidney only. In dogs running at 3.6 m/s
renal hemodynamics decreased significantly and similarly for both kidneys,
whereas the fall in renal excretion was virtually limited to the denervated
kidney. As glomerular filtration rate (GFR) was falling during exercise,
sodium excretion per 100 ml GFR tended to increase in the innervated
kidney, in contrast to an expected slight fall on the denervated side. This
indicated a defect of tubular sodium reabsorption of the innervated kidney.
On the whole, the data do not support an important mediatory role of renal
nerves in the mechanism of renal function changes during exercise.
