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J Appl Physiol 51: 1539-1542, 1981;
8750-7587/81 $5.00
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Journal of Applied Physiology, Vol 51, Issue 6 1539-1542, Copyright © 1981 by American Physiological Society

ARTICLES

Effect of an exercise run to exhaustion on cAMP in the rat heart

A. H. Goldfarb and Z. V. Kendrick

The purpose of this investigation was to determine whether adenosine 3',5'-cyclic monophosphate (cAMP) content is increased in vivo in the heart as a result of exercise at a time when there is rapid cardiac glycogen utilization. Rats were run to exhaustion on a treadmill for a period of 164.5 +/- 9.5 min. Blood norepinephrine and epinephrine were significantly elevated approximately 2.5-fold above resting levels at the end of the treadmill run. Myocardial glycogen was reduced by 54.7% at exhaustion compared with control values. Myocardial cAMP was significantly elevated 88% above control levels as a result of the run. Associated with the depletion of myocardial glycogen and the elevation of cAMP was an activation of phosphorylase to its a form. These data suggest that myocardial glycogen metabolism during exercise is, in part, mediated by hormonal influences that are associated with increases in cAMP.


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