Journal of Applied Physiology Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 51: 1423-1427, 1981;
8750-7587/81 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hirshman, C. A.
Right arrow Articles by Peters, J. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hirshman, C. A.
Right arrow Articles by Peters, J. E.

Journal of Applied Physiology, Vol 51, Issue 6 1423-1427, Copyright © 1981 by American Physiological Society

ARTICLES

Basenji-greyhound dog model of asthma: pulmonary responses after beta-adrenergic blockade

C. A. Hirshman, H. Downes, D. A. Leon and J. E. Peters

To understand the mechanism underlying bronchial hyperreactivity in the Basenji-Greyhound (BG) dog, the effects of propranolol (2 mg/kg) and hexamethonium (5 mg/kg) on base-line pulmonary mechanics and on the bronchial response to aerosol challenges of citric acid and methacholine were studied in five BG dogs. Both propranolol and hexamethonium increased base-line pulmonary resistance (RL) from 0.69 +/- 0.05 (means +/- SE) cmH2O.l-1.s to 1.67 +/- 0.10 (P less than 0.05) and 2.22 +/- 0.45 cmH2O.1-1.s (P less than 0.05) and decreased dynamic compliance (Cdyn) from 190 +/- 10 ml/cmH2O to 154 +/- 9 (P less than 0.05) and 140 +/- 9 (P less than 0.05) ml/cmH2O, respectively. Both propranolol and hexamethonium potentiated the pulmonary response to 10% citric acid given for 5 min (P less than 0.05). RL postchallenge was 4.4 +/- 0.23, 8.1 +/- 0.81, and 7.8 +/- 0.31 cmH2O.l-1.s, and Cdyn was 78 +/- 5, 58 +/- 6, and 51 +/- 3 ml/cmH2O in untreated, propranolol-pretreated, and hexamethonium-pretreated animals. In untreated BG dogs, methacholine (0.075 mg/ml) increased RL from 0.94 +/- 0.25 to 2.2 +/- 0.21 cmH2O.l-1.s (234%) and decreased Cdyn from 223 +/- 39 to 141 +/- 14 ml/cmH2O (63%). In the same animals pretreated with propranolol, methacholine (0.075 mg/ml) increased RL from 1.9 +/- 0.66 to 4.8 +/- 1.37 cmH2O.l-1.s (253%) and decreased Cdyn from 144 +/- 35 to 81 +/- 15 ml/cmH2O (56%). We conclude that propranolol produces airway constriction in BG dogs, as in asthmatic humans and that the effects of propranolol on airways in BG dogs are not due to parasympathetic or alpha-adrenergic predominance.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
B. J. Canning
Reflex regulation of airway smooth muscle tone
J Appl Physiol, September 1, 2006; 101(3): 971 - 985.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online