Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 51: 1065-1071, 1981;
8750-7587/81 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mitzner, W.
Right arrow Articles by Sylvester, J. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mitzner, W.
Right arrow Articles by Sylvester, J. T.

Journal of Applied Physiology, Vol 51, Issue 5 1065-1071, Copyright © 1981 by American Physiological Society

ARTICLES

Hypoxic vasoconstriction and fluid filtration in pig lungs

W. Mitzner and J. T. Sylvester

We have studied the effect of hypoxia [inspired partial pressure of O2 (Po2) 50 mmHg] on the relationships among pulmonary blood flow, pulmonary arterial pressure, and fluid filtration rates in isolated blood-perfused pig lungs. Our results indicate that hypoxia constricted the vasculature in a manner that caused a parallel shift of the pressure-flow curve to higher pressures. During normoxia, filtration rate was zero at flows less than 1.5 1/min but increased with increases in blood flow above this level. In both cases the shape of this relationship was similar, but during hypoxia it was shifted to higher filtration rates. These findings can be interpreted using a parallel-channel Starling resistor model of the lung with a distribution of critical pressures. All the effects of hypoxia found in this study could be explained simply by an increase in critical pressure. According to the model, this increase in critical pressure during hypoxia caused a greater filtration rate because of an increase in the mean intravascular filtration pressure and an increase in the mean filtration coefficient.


This article has been cited by other articles:


Home page
 Cardiovasc ResHome page
M. Maggiorini
High altitude-induced pulmonary oedema
Cardiovasc Res, October 1, 2006; 72(1): 41 - 50.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
F. Spohr, A. J. M. Cornelissen, C. Busch, M. M. Gebhard, J. Motsch, E. O. Martin, and J. Weimann
Role of endogenous nitric oxide in endotoxin-induced alteration of hypoxic pulmonary vasoconstriction in mice
Am J Physiol Heart Circ Physiol, August 1, 2005; 289(2): H823 - H831.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. Maggiorini and F. Leon-Velarde
High-altitude pulmonary hypertension: a pathophysiological entity to different diseases
Eur. Respir. J., December 1, 2003; 22(6): 1019 - 1025.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C.-C. Yu and Y.-L. Lai
In vivo pressure-flow curve in unilateral rat lung ischemia-reperfusion injury
J Appl Physiol, May 1, 2001; 90(5): 1865 - 1870.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. V. Clough, S. T. Haworth, W. Ma, and C. A. Dawson
Effects of hypoxia on pulmonary microvascular volume
Am J Physiol Heart Circ Physiol, September 1, 2000; 279(3): H1274 - H1282.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. C. FLETCHER, M. PROCTOR, J. YU, J. ZHANG, J. J. GUARDIOLA, C. HORNUNG, and G. BAO
Pulmonary Edema Develops after Recurrent Obstructive Apneas
Am. J. Respir. Crit. Care Med., November 1, 1999; 160(5): 1688 - 1696.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
G. Cremona, T. Higenbottam, M. Takao, E. A. Bower, and L. W. Hall
Nature and site of action of endogenous nitric oxide in vasculature of isolated pig lungs
J Appl Physiol, January 1, 1997; 82(1): 23 - 31.
[Abstract] [Full Text] [PDF]

Home page
 ANGIOLOGYHome page
Shian Gu, R. M. Prewitt, U. Schick, and J. Ducas
Effects of Progressive Vascular Occlusion on Slope and Intercept of the Pulmonary Artery Pressure-Flow Relationship
Angiology, January 1, 1995; 46(1): 45 - 52.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online