Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 51: 845-851, 1981;
8750-7587/81 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Johnson, R. L.
Right arrow Articles by Schulz, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Johnson, R. L., Jr
Right arrow Articles by Schulz, W.

Journal of Applied Physiology, Vol 51, Issue 4 845-851, Copyright © 1981 by American Physiological Society

ARTICLES

Microvascular injury distal to unilateral pulmonary artery occlusion

R. L. Johnson Jr, S. S. Cassidy, M. Haynes, R. L. Reynolds and W. Schulz

We explored three questions: 1) does edema fluid accumulate distal to temporary unilateral pulmonary artery occlusion (TUPAO); 2) if so how rapidly does it accumulate; and 3) how is it affected by positive end-expiratory pressure (PEEP)? Using a tracheal divider we measured pulmonary capillary blood flow (Qc), tissue volume (Vt), and diffusing capacity (DLCO) in each lung with a rebreathing method. After control measurements in 12 dogs, the left pulmonary artery was occluded and measurements were repeated at intervals during 4 h of occlusion and 30 min after release of the occlusion. Six of the dogs were ventilated with 10 cmH2O PEEP. Finally the lungs were removed, weighed, and fixed for histology. TUPAO caused a 29% increase in Vt of the left lung without PEEP and a 59% increase with PEEP. After release of the occlusion, Qc and DLCO in the left lung returned to control levels within 30 min in dogs not on PEEP but remained depressed in dogs ventilated with PEEP even though PEEP was removed. At postmortem the left lung weighed more than expected in both groups of dogs but was significantly heavier in those on PEEP. Histology confirmed bronchovascular cuffing with edema and hemorrhage.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
C. C. W. Hsia
Signals and mechanisms of compensatory lung growth
J Appl Physiol, November 1, 2004; 97(5): 1992 - 1998.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. A. Kazi, W. S. Lee, E. Wagner, and P. M. Becker
VEGF, fetal liver kinase-1, and permeability increase during unilateral lung ischemia
Am J Physiol Lung Cell Mol Physiol, September 1, 2000; 279(3): L460 - L467.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. FADEL, G.-M. MAZMANIAN, A. CHAPELIER, B. BAUDET, H. DETRUIT, V. de MONTPREVILLE, J.-M. LIBERT, M. WARTSKI, P. HERVE, and P. DARTEVELLE
Lung Reperfusion Injury after Chronic or Acute Unilateral Pulmonary Artery Occlusion
Am. J. Respir. Crit. Care Med., April 1, 1998; 157(4): 1294 - 1300.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
D. Ranney
Targeted modulation of acute inflammation
Science, January 11, 1985; 227(4683): 182 - 184.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online