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J Appl Physiol 51: 798-805, 1981;
8750-7587/81 $5.00
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Journal of Applied Physiology, Vol 51, Issue 4 798-805, Copyright © 1981 by American Physiological Society

ARTICLES

Extrapericardial and esophageal pressures with positive end-expiratory pressure in dogs

K. D. Craven and L. D. Wood

Using flat balloon techniques to minimize distortion and artifacts, we studied the effect of positive end-expiratory pressure (PEEP) on local surface pressures between the lung and pericardium overlying the right (R) and left (L) ventricles of ventilated closed-chest anesthetized dogs in right lateral decubitus position. To test the hypothesis that local extrapericardial [Pep(L) and Pep(R)] and average pleural pressures change equally with PEEP, we also measured esophageal pressure (Pes). When 10-cmH2O PEEP was applied, mean increases in Pes, Pep(L), and Pep(R) were 6.2, 5.6, and 5.3 cmH2O, respectively. When PEEP was raised to 20 cmH2O, further average increases in Pes, Pep(L), and Pep(R) were 5.8, 5.0, and 5.4 cmH2O. At each level of PEEP, volume infusion was used to increase stroke volume. Volume infusion at 20-cmH2O PEEP was associated with small 1.0- and 1.5-cmH2O increases in Pep but no change in Pes. Analysis of confidence limits showed that application of up to 20-cmH2O PEEP, with or without volume infusion to restore stroke volume, is associated with nearly equal changes in esophageal and local extrapericardial pressures.


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 Am. J. Physiol. Heart Circ. Physiol.Home page
M. Kleen, B. Zwissler, and K. Messmer
PEEP only partly restores disturbed distribution of regional pulmonary blood flow in lung injury
Am J Physiol Heart Circ Physiol, January 1, 1998; 274(1): H209 - H216.
[Abstract] [Full Text] [PDF]


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