Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 51: 788-793, 1981;
8750-7587/81 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Twentyman, O. P.
Right arrow Articles by Tattersfield, A. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Twentyman, O. P.
Right arrow Articles by Tattersfield, A. E.

Journal of Applied Physiology, Vol 51, Issue 4 788-793, Copyright © 1981 by American Physiological Society

ARTICLES

Effect of beta-adrenergic blockade on respiratory and metabolic responses to exercise

O. P. Twentyman, A. Disley, H. R. Gribbin, K. G. Alberti and A. E. Tattersfield

The responses to oral propranolol (80 mg) and placebo were compared in normal subjects during three studies on a cycle ergometer (progressive exercise and two 5-min constant work rate studies at 50 and 70% maximum). Heart rate (HR), ventilation (VE), CO2 output (VCO2) and O2 uptake (VO2) were measured in each study and metabolites in venous blood in the 70% study. Propranolol reduced HR in all studies and endurance time during progressive exercise. During constant-work-rate exercise the changes with propranolol depended on time and work rate. At 50% max, VO2, VCO2, and VE were reduced in early exercise but were similar by min 5. At 70% max, VO2 and VCO2 were again lower initially with propranolol but then rose more rapidly. By min 5 VE was greater with propranolol, coinciding with a rapidly rising venous lactate. We interpret the initial reduction in VO2 and VCO2 to reduced cardiac output and muscle perfusion with propranolol. The resulting increase in anaerobic metabolism during heavy exercise would explain the increased VE at min 5. The metabolic data are compatible with glycogen being the predominant muscle fuel.


This article has been cited by other articles:


Home page
 ChestHome page
S. Grant, T. Aitchison, E. Henderson, J. Christie, S. Zare, J. McMurray, and H. Dargie
A Comparison of the Reproducibility and the Sensitivity to Change of Visual Analogue Scales, Borg Scales, and Likert Scales in Normal Subjects During Submaximal Exercise
Chest, November 1, 1999; 116(5): 1208 - 1217.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. Wasserman, W. W. Stringer, R. Casaburi, and Y.-Y. Zhang
Mechanism of the exercise hyperkalemia: an alternate hypothesis
J Appl Physiol, August 1, 1997; 83(2): 631 - 643.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online