Journal of Applied Physiology
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J Appl Physiol 51: 571-576, 1981;
8750-7587/81 $5.00
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Journal of Applied Physiology, Vol 51, Issue 3 571-576, Copyright © 1981 by American Physiological Society

ARTICLES

Pulmonary diffusing capacity for CO independent of alveolar CO concentration

M. Meyer, W. Lessner, P. Scheid and J. Piiper

Pulmonary diffusing capacity for CO (DCO) was measured in human subjects at various CO concentrations using a rebreathing procedure. Two stable CO isotopes, 12C18O and 13C18O, were used. These isotopes could be simultaneously and continuously recorded by a respiratory mass spectrometer. For 13C18O the initial concentration in the rebreathing bag was constant at 0.00016, whereas it was varied for 12C18O from 0 to 0.00224. DCO was calculated for both isotopes. In five normal subjects, both D12C18O and D13C18O were independent of the rebreathing CO concentration, with mean values of 31.0 and 30.2 ml . min-1 . Torr-1, respectively. These results, which are at variance with those of Mendoza et al. (J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 43: 880-884, 1977), are compatible with the assumption that diffusion is the sole mechanism of alveolocapillary CO transport; in particular, there is no evidence for facilitated transport.




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