Journal of Applied Physiology Journal of Neurophysiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 51: 509-515, 1981;
8750-7587/81 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hawco, M. W.
Right arrow Articles by Keough, K. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hawco, M. W.
Right arrow Articles by Keough, K. M.

Journal of Applied Physiology, Vol 51, Issue 2 509-515, Copyright © 1981 by American Physiological Society

ARTICLES

Lipid fluidity in lung surfactant: monolayers of saturated and unsaturated lecithins

M. W. Hawco, P. J. Davis and K. M. Keough

Monolayers of saturated or unsaturated lecithins (PCs) could be compressed to near-zero surface tension (gamma) when they were below the gel-to-liquid crystalline transition temperature (Tc) of the PC, whereas, when above Tc, they collapsed at gamma of 15-23 mN X m-1. Thus PCs with ordered, but not necessarily saturated, chains are required to achieve low gamma. At 37 degrees C the minimum gamma reached by monolayers containing dipalmitoyl PC (DPPC; Tc = 41 degrees C) plus 1-stearoyl-2-oleoyl PC (SOPC; Tc = 6 degrees C) depended on the proportions of the two lipids and the compression rate. When compressed at 1 cm2 X s-1, monolayers of mixtures containing less than 50% SOPC were capable of achieving gamma less than 9 mN X m-1. When the proportion of unsaturated lecithin was high (70%), compression at 1 cm2 X s-1 was insufficient to form a monolayer capable of reaching a very low surface tension. Exclusion of fluid lipid during compression could account for these observations.


This article has been cited by other articles:


Home page
 Biophys. JHome page
E. C. Smith, J. M. Crane, T. G. Laderas, and S. B. Hall
Metastability of a Supercompressed Fluid Monolayer
Biophys. J., November 1, 2003; 85(5): 3048 - 3057.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
R. Schmidt, U. Meier, P. Markart, F. Grimminger, H. G. Velcovsky, H. Morr, W. Seeger, and A. Gunther
Altered fatty acid composition of lung surfactant phospholipids in interstitial lung disease
Am J Physiol Lung Cell Mol Physiol, November 1, 2002; 283(5): L1079 - L1085.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
E. P. Ingenito, L. Mark, J. Morris, F. F. Espinosa, R. D. Kamm, and M. Johnson
Biophysical characterization and modeling of lung surfactant components
J Appl Physiol, May 1, 1999; 86(5): 1702 - 1714.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
Z. WANG, O. GUREL, S. WEINBACH, and R. H. NOTTER
Primary Importance of Zwitterionic Over Anionic Phospholipids in the Surface-active Function of Calf Lung Surfactant Extract
Am. J. Respir. Crit. Care Med., October 1, 1997; 156(4): 1049 - 1057.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Z. Wang, O. Gurel, J. E. Baatz, and R. H. Notter
Acylation of Pulmonary Surfactant Protein-C Is Required for Its Optimal Surface Active Interactions with Phospholipids
J. Biol. Chem., August 9, 1996; 271(32): 19104 - 19109.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online