Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 51: 288-292, 1981;
8750-7587/81 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Parsons, G. H.
Right arrow Articles by Goldstein, J. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Parsons, G. H.
Right arrow Articles by Goldstein, J. D.

Journal of Applied Physiology, Vol 51, Issue 2 288-292, Copyright © 1981 by American Physiological Society

ARTICLES

Effect of sodium nitroprusside on hypoxic pulmonary vasoconstriction in the dog

G. H. Parsons, J. P. Leventhal, M. M. Hansen and J. D. Goldstein

The objective of the study was to determine the direct actions of sodium nitroprusside (SNP) on the pulmonary vasculature actively constricted by hypoxic ventilation in the closed-chest dog. In 21 supine anesthetized (pentobarbital sodium, 25 mg/kg) dogs the left lower lobe was catheterized with a 20 F wedged-flow catheter. With constant flow to this lung lobe, lobar pulmonary artery pressure (PAP), left ventricular end-diastolic pressure (LVEDP), and lobar pulmonary vascular resistance (PVR) were studied during room air and 10% O2 mechanical ventilation. With lobar flow and LVEDP constant, observed changes of lobar PAP and PVR represent direct effects on vascular tone unaffected by passive factors. Ventilation with 10% O2 resulted in a significant increase in lobar PAP [12.2 +/- 1.6 to 17.2 +/- 1.2 (SE) Torr] and PVR [42.2 +/- 13.3 to 61.2 +/- 15.0 (SE) Torr X 1(-1) X min]. Then during continued hypoxia in 12 animals, femoral vein infusion of SNP at doses of 1, 2, and 5 microgram X kg-1 X min-1 resulted in significant decreases in lobar PAP to 14.8 +/- 1.5, 14.8 +/- 1.5, and 13.4 +/- 1.6 Torr, respectively, and in PVR to 56.7 +/- 14.1, 54.0 +/- 13.9, and 47.8 %/- 13.2 Torr X 1(-1) X min, respectively. In six animals the sequence of drug infusion was then reversed with similar results. It is concluded that the actively constricted pulmonary vascular bed is directly dilated by SNP infusion.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
P. Fesler, A. Pagnamenta, B. Rondelet, F. Kerbaul, and R. Naeije
Effects of sildenafil on hypoxic pulmonary vascular function in dogs
J Appl Physiol, October 1, 2006; 101(4): 1085 - 1090.
[Abstract] [Full Text] [PDF]

Home page
 SEMIN CARDIOTHORAC VASC ANESTHHome page
M. L. Fisher and S. C. Body
Physiology of One-Lung Ventilation
Seminars in Cardiothoracic and Vascular Anesthesia, September 1, 1997; 1(3): 236 - 255.
[Abstract] [PDF]

Home page
 J Intensive Care MedHome page
M. V. Cutaia and S. Rounds
Analytic Reviews : Hypoxic Pulmonary Vasoconstriction: Physiology and Pathophysiology
J Intensive Care Med, September 1, 1989; 4(5): 186 - 191.
[Abstract] [PDF]

Home page
 J Intensive Care MedHome page
V. Courtney Broaddus, Y. Berthiaume, J. W. Biondi, and M. A. Matthay
Analytic Reviews : Hemodynamic Management of the Adult Respiratory Distress Syndrome
J Intensive Care Med, August 1, 1987; 2(4): 190 - 213.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online