Journal of Applied Physiology, Vol 51, Issue 1 73-77, Copyright © 1981 by American Physiological Society

ARTICLES

Protein synthesis rates in atrophied gastrocnemius muscles after limb immobilization

K. R. Tucker, M. J. Seider and F. W. Booth

Fractional rates of protein synthesis in rats were determined by the constant-infusion technique. Rates of protein synthesis in the gastrocnemius muscle were significantly reduced from control values throughout a 7-day period of hindlimb immobilization and 1) significantly increased to control values during the first 6 h following the 7-day period of hindlimb immobilization; 2) remained at control values for the next 2 days; and 3) then significantly increased to about twice control values on the 4th day following immobilization. Exercise of sufficient duration and/or intensity affected a further increase in the protein synthesis rate during recovery from atrophy. For example, running on a motor-driven treadmill 1 h daily for 3 days after ending limb immobilization resulted in a significant increase in the fractional rate of protein synthesis in the gastrocnemius muscle on the 2nd day following immobilization. Also, weight lifting for 200 s on the 2nd day of protein synthesis in the gastrocnemius muscle. Thus increased usage of atrophied muscle was followed by an increased rate of protein synthesis.

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