Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 50: 1140-1145, 1981;
8750-7587/81 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schaible, T. F.
Right arrow Articles by Scheuer, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schaible, T. F.
Right arrow Articles by Scheuer, J.

Journal of Applied Physiology, Vol 50, Issue 6 1140-1145, Copyright © 1981 by American Physiological Society

ARTICLES

Cardiac function in hypertrophied hearts from chronically exercised female rats

T. F. Schaible and J. Scheuer

Physiological cardiac hypertrophy was produced in female rats by subjecting them to a swimming program for 8 wk. Conditioned rats (C) had body weights similar to sedentary control rats (S), but hearts from C weighed 33% more than hearts from S. Heart function was assessed in an isolated working-heart apparatus at similar heart rates and aortic diastolic pressures and over a range of 5-20 cmH2O left atrial filling pressure (LAP). At any given LAP, absolute values for cardiac output and coronary flow were greater (p less than 0.001) in C than S, but when these values were normalized for dry left ventricular (LV) weight, no differences were observed. Peak LV systolic pressure and ejection fraction were greater (p less than 0.01) in C than S at all LAP. Derived measures of contractility calculated at the midwall demonstrated greater (p less than 0.01) velocity and extent of circumferential fiber shortening in C compared with S. Therefore, chronic swimming in female rats leads to enhanced contractile performance of the left ventricle despite a marked degree of hypertrophy. These results contrast with our earlier observations in female rats trained by running where neither hypertrophy nor enhanced function were observed.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. P. Konhilas, A. H. Maass, S. W. Luckey, B. L. Stauffer, E. N. Olson, and L. A. Leinwand
Sex modifies exercise and cardiac adaptation in mice
Am J Physiol Heart Circ Physiol, December 1, 2004; 287(6): H2768 - H2776.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
U. Wisloff, J. Helgerud, O. J. Kemi, and O. Ellingsen
Intensity-controlled treadmill running in rats: {V}O2 max and cardiac hypertrophy
Am J Physiol Heart Circ Physiol, March 1, 2001; 280(3): H1301 - H1310.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
R.M Mohan, J.K Choate, S Golding, N Herring, B Casadei, and D.J Paterson
Peripheral pre-synaptic pathway reduces the heart rate response to sympathetic activation following exercise training: role of NO
Cardiovasc Res, July 1, 2000; 47(1): 90 - 98.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online