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J Appl Physiol 50: 1104-1110, 1981;
8750-7587/81 $5.00
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Journal of Applied Physiology, Vol 50, Issue 5 1104-1110, Copyright © 1981 by American Physiological Society

ARTICLES

Fast integrated flow plethysmograph for small mammals

E. E. Sinnett, A. C. Jackson, D. E. Leith and J. P. Butler

The accurate measurement of a forced vital capacity (FVC) maneuver in a small mammal requires that the plethysmograph in use have good response characteristics at high frequencies. We develop, on a theoretical basis, the behavior of zeroth-order (pressure type), first-order (flow type without inertance), and second-order (flow type with inertance) plethysmogrphs. The actual frequency response of a mouse-sized plethysmograph is then presented, and a technique for improving its response characteristics is described. A flat amplitude response (within 3% of a reference flow taken as truth) was obtained for sinusoidal inputs below 240 Hz. A phase lag with respect to the reference flow equivalent to a simple time delay of 1.4 ms was observed up to 150 Hz. A typical FVC curve for a mouse is shown, and criteria are provided for designing similar plethysmographs suitable for use with larger animals.


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