Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 50: 374-382, 1981;
8750-7587/81 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yip, P.
Right arrow Articles by Coburn, R. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yip, P.
Right arrow Articles by Coburn, R. F.

Journal of Applied Physiology, Vol 50, Issue 2 374-382, Copyright © 1981 by American Physiological Society

ARTICLES

Inhibitory innervation to the guinea pig trachealis muscle

P. Yip, B. Palombini and R. F. Coburn

The inhibitory innervation of the cervical trachea was studied in situ in anesthetized male guinea pigs. We measured effects of electrical stimulation of vagal motor and sympathetic trunk nerve fibers, during atropine, on trachealis muscle tension. Effects of direct transmural stimulation of trachealis muscle were also determined. We confirmed the dual nature of the inhibitory innervation to this muscle. Vagal motor inhibitory nerves are shown to be preganglionic. Neural transmission at the level of the ganglia is characterized by filtering of high frequency action potentials. The neurotransmitter at the myoneural junction is unidentified but is not norepinephrine. Maximal relaxation accounts for about 20-40% of maximal relaxations seen with transmural stimulation of trachealis muscle in the presence of atropine. Sympathetic trunk nerve fibers are also preganglionic. Neurotransmission at the level of the ganglia is apparently 1:1 at high-action potential frequencies. Norepinephrine released presynaptically has access to smooth muscle beta- but not alpha-receptors. Maximal adrenergic relaxations account for 60-80% of total transmural stimulation relaxations. Transmural stimulation relaxations appear to be accounted for by release of neurotransmitter from sympathetic adrenergic plus vagal nonadrenergic postganglionic nerve fibers.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
Z.-X. Wu, B. E. Satterfield, J. S. Fedan, and R. D. Dey
Interleukin-1beta -induced airway hyperresponsiveness enhances substance P in intrinsic neurons of ferret airway
Am J Physiol Lung Cell Mol Physiol, November 1, 2002; 283(5): L909 - L917.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
B. S. KESLER, S. B. MAZZONE, and B. J. CANNING
Nitric Oxide-dependent Modulation of Smooth-Muscle Tone by Airway Parasympathetic Nerves
Am. J. Respir. Crit. Care Med., February 15, 2002; 165(4): 481 - 488.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
W. Zhu and R. D. Dey
Projections and Pathways of VIP- and nNos-Containing Airway Neurons in Ferret Trachea
Am. J. Respir. Cell Mol. Biol., January 1, 2001; 24(1): 38 - 43.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
S. C. Iben, I. A. Dreshaj, C. F. Farver, M. A. Haxhiu, and R. J. Martin
Role of endogenous nitric oxide in hyperoxia-induced airway hyperreactivity in maturing rats
J Appl Physiol, September 1, 2000; 89(3): 1205 - 1212.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. Chitano, C. M. Cox, and T. M. Murphy
Relaxation of guinea pig trachealis during electrical field stimulation increases with age
J Appl Physiol, May 1, 2002; 92(5): 1835 - 1842.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online