Journal of Applied Physiology Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 50: 172-177, 1981;
8750-7587/81 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Donnelly, D. F.
Right arrow Articles by Dutton, R. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Donnelly, D. F.
Right arrow Articles by Dutton, R. E.

Journal of Applied Physiology, Vol 50, Issue 1 172-177, Copyright © 1981 by American Physiological Society

ARTICLES

Neural response of carotid chemoreceptors following dopamine blockade

D. F. Donnelly, E. J. Smith and R. E. Dutton

The role of endogenous carotid body dopamine in the afferent chemoreceptor circuit was studied by means of haloperidol-induced dopamine antagonism. In 19 cats that were anesthetized with pentobarbital sodium and paralyzed, single carotid body nerve fibers were dissected free and placed on unipolar platinum wire electrodes. In 10 of these cats, the neural response to room air and the last 2 min of 6-min inhalations of 3, 6, and 9% CO2 were recorded, and blood samples were drawn for gas tension measurements. Haloperidol was administered at a dose (250 micrograms/kg) shown to block the inhibitory effect of injected dopamine. Following a 15-min equilibration, the CO2 response was again tested. In four other cats the CO2 response was tested with a hyperoxic background. In the remaining five cats the response to isocapnic hypoxia was recorded during administration of 15, 12, and 8% O2 before and following haloperidol. There was a significant increase in room air discharge activity and in hypoxic sensitivity following haloperidol. However, there was no significant change in hypercapnic sensitivity. These results suggest that there is a modulatory role for endogenous dopamine only in the hypoxic response.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
J. Prieto-Lloret, D. F. Donnelly, A. J. Rico, R. Moratalla, C. Gonzalez, and R. J. Rigual
Hypoxia transduction by carotid body chemoreceptors in mice lacking dopamine D2 receptors
J Appl Physiol, October 1, 2007; 103(4): 1269 - 1275.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H. Nakano, S.-D. Lee, and G. A. Farkas
Dopaminergic modulation of ventilation in obese Zucker rats
J Appl Physiol, January 1, 2002; 92(1): 25 - 32.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. F. Donnelly
Developmental aspects of oxygen sensing by the carotid body
J Appl Physiol, June 1, 2000; 88(6): 2296 - 2301.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. F. Donnelly and R. Rigual
Single-unit recordings of arterial chemoreceptors from mouse petrosal ganglia in vitro
J Appl Physiol, April 1, 2000; 88(4): 1489 - 1495.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online